caa a22 4500 445316217 CHVBK 20180317142648.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s10552-011-9830-8 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9830-8 A case-control study of reproductive factors and renal cell carcinoma among black and white women in the United States [Elektronische Daten] [Mark Purdue, Joanne Colt, Barry Graubard, Faith Davis, Julie Ruterbusch, Ralph DiGaetano, Sara Karami, Sholom Wacholder, Kendra Schwartz, Wong-Ho Chow] Objective: Renal cell carcinoma (RCC) incidence is higher among blacks than whites in the United States and has been associated with the frequency and timing of childbirth among women in some epidemiologic studies. We investigated whether reproductive factors are associated with RCC, overall and by race, within a population-based case-control study. Methods: Between 2002 and 2007, 497 female cases of incident RCC (136 black, 361 white) and 546 female controls (273 black, 273 white) within the Detroit and Chicago metropolitan areas were enrolled. Information on reproductive history and other factors was collected through in-person interviews. Multivariate-adjusted odds ratios (OR) and 95% confidence intervals (CI) were computed using unconditional logistic regression. Results: Reduced RCC risk was observed among women aged ≥30years at first live birth, relative to an age of <20years (OR 0.5, 95% CI 0.3-0.9). This association was present among both white (OR 0.4, 95% CI 0.2-0.9) and, though not statistically significant, black women (OR 0.6, 95% CI 0.2-1.8). In analyses restricted to clear cell adenocarcinoma, the most common RCC histological subtype, the association was particularly strong (OR 0.3, 95% CI 0.2-0.8). We did not observe clear evidence of association with RCC for other reproductive factors. Conclusions: Our findings further support an association between late maternal age at first birth and reduced RCC risk, and suggest that the association may be particularly strong for clear cell adenocarcinoma. Springer Science+Business Media B.V. (outside the USA), 2011 Renal cell carcinoma nationallicence Reproductive factors nationallicence Case-control studies nationallicence Hysterectomy nationallicence Parity nationallicence Purdue Mark Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Room 8114, 20892-7240, Bethesda, MD, USA aut Colt Joanne Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Room 8114, 20892-7240, Bethesda, MD, USA aut Graubard Barry Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Room 8114, 20892-7240, Bethesda, MD, USA aut Davis Faith University of Illinois at Chicago, Chicago, IL, USA aut Ruterbusch Julie Karmanos Cancer Institute and Department of Family Medicine, Wayne State University, Detroit, MI, USA aut DiGaetano Ralph Westat, Inc., Rockville, MD, USA aut Karami Sara Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Room 8114, 20892-7240, Bethesda, MD, USA aut Wacholder Sholom Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Room 8114, 20892-7240, Bethesda, MD, USA aut Schwartz Kendra Karmanos Cancer Institute and Department of Family Medicine, Wayne State University, Detroit, MI, USA aut Chow Wong-Ho Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Room 8114, 20892-7240, Bethesda, MD, USA aut Cancer Causes & Control Springer Netherlands 22/11(2011-11-01), 1537-1544 0957-5243 22:11<1537 2011 22 10552 https://doi.org/10.1007/s10552-011-9830-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9830-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Purdue Mark Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Room 8114, 20892-7240, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Colt Joanne Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Room 8114, 20892-7240, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Graubard Barry Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Room 8114, 20892-7240, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Davis Faith University of Illinois at Chicago, Chicago, IL, USA aut NATIONALLICENCE 700 1- Ruterbusch Julie Karmanos Cancer Institute and Department of Family Medicine, Wayne State University, Detroit, MI, USA aut NATIONALLICENCE 700 1- DiGaetano Ralph Westat, Inc., Rockville, MD, USA aut NATIONALLICENCE 700 1- Karami Sara Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Room 8114, 20892-7240, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Wacholder Sholom Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Room 8114, 20892-7240, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Schwartz Kendra Karmanos Cancer Institute and Department of Family Medicine, Wayne State University, Detroit, MI, USA aut NATIONALLICENCE 700 1- Chow Wong-Ho Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Room 8114, 20892-7240, Bethesda, MD, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/11(2011-11-01), 1537-1544 0957-5243 22:11<1537 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer