caa a22 4500 445316225 CHVBK 20180317142648.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s10552-011-9826-4 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9826-4 Merkel cell carcinoma: a population-based study on mortality and the association with other cancers [Elektronische Daten] [Valeria Ascoli, Giada Minelli, Mark Kanieff, Luisa Frova, Susanna Conti] Background: Few population-based epidemiological data are available on Merkel cell carcinoma (MCC), a rare lethal non-melanoma skin cancer. We analysed multiple-cause-of-death records to describe MCC mortality and trends and the association with other primary cancers. Methods: We reviewed all 6,713,059 death certificates in Italy (1995-2006) to identify those mentioning MCC. We evaluated the association with other primary cancers by calculating the ratio of observed to expected deaths, using a standardized mortality ratio (SMR)-like analysis. We also evaluated the geographic distribution of deaths. Results: We identified 351 death certificates with the mention of MCC. The age-adjusted mortality was 0.031/100,000, with a significant trend of increase and a slight north-south gradient. There was a significant deficit for solid cancers (SMR=0.15) and a non-significant excess for lymphohematopoietic malignancies (SMR=1.62). There were significant excesses for chronic lymphocytic leukemia (SMR=4.07) and Waldenström's macroglobulinemia (SMR=27.2) and a non-significant excess for chronic myeloid leukemia (SMR=5.12). Conclusions: The increase in MCC mortality reflects the incidence trend in the literature. The association with chronic lymphocytic leukemia confirms the importance of immunologic factors in MCC. Regarding Waldenström's macroglobulinemia, an association with MCC has never been reported. The Author(s), 2011 Multiple-cause-of-death nationallicence Non-melanoma skin cancer nationallicence Waldenström's macroglobulinemia nationallicence Chronic lymphocytic leukemia nationallicence Neuroendocrine carcinoma nationallicence Ascoli Valeria Dipartimento di Scienze Radiologiche, Oncologiche e Anatomo-Patologiche, Università La Sapienza, Viale Regina Elena 324, 00161, Rome, Italy aut Minelli Giada Ufficio di Statistica, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy aut Kanieff Mark Ufficio di Statistica, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy aut Frova Luisa Servizio Sanità e Assistenza, ISTAT, Viale Liegi 13, 00198, Rome, Italy aut Conti Susanna Ufficio di Statistica, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy aut Cancer Causes & Control Springer Netherlands 22/11(2011-11-01), 1521-1527 0957-5243 22:11<1521 2011 22 10552 https://doi.org/10.1007/s10552-011-9826-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9826-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ascoli Valeria Dipartimento di Scienze Radiologiche, Oncologiche e Anatomo-Patologiche, Università La Sapienza, Viale Regina Elena 324, 00161, Rome, Italy aut NATIONALLICENCE 700 1- Minelli Giada Ufficio di Statistica, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy aut NATIONALLICENCE 700 1- Kanieff Mark Ufficio di Statistica, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy aut NATIONALLICENCE 700 1- Frova Luisa Servizio Sanità e Assistenza, ISTAT, Viale Liegi 13, 00198, Rome, Italy aut NATIONALLICENCE 700 1- Conti Susanna Ufficio di Statistica, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/11(2011-11-01), 1521-1527 0957-5243 22:11<1521 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer