caa a22 4500 44531625X CHVBK 20180317142648.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s10552-011-9832-6 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9832-6 Regular aspirin use and breast cancer risk in US Black Women [Elektronische Daten] [Jaclyn Bosco, Julie Palmer, Deborah Boggs, Elizabeth Hatch, Lynn Rosenberg] Background: Epidemiologic studies have yet to provide consistent evidence to support a protective effect of aspirin and other non-steroidal anti-inflammatory drugs (NSAID) on the incidence of breast cancer. Objective: We evaluated the relations of current use of aspirin, non-aspirin NSAIDs, and acetaminophen with breast cancer incidence in the Black Women's Health Study. Methods: Biennial follow-up of 59,000 study participants began in 1995. During 558,600 person-years of follow-up through 2007, 1,275 breast cancer cases were identified. Using Cox proportional hazards regression, we estimated incidence rate ratios (IRR) and 95% confidence intervals (CI) for associations of current and former use of aspirin, other NSAIDs, and acetaminophen with incident breast cancer. Results: After adjustment for age, education, body mass index at age 18, physical activity, female hormone use, current smoking, and other NSAID use, the IRRs were 0.79 (95% CI=0.66, 0.95) for current aspirin use and 0.68 (95% CI=0.50, 0.92) for ≥5years of aspirin use. Similar associations were observed for acetaminophen use. Conclusions: Both aspirin and acetaminophen use were inversely associated with breast cancer incidence in the present study. Reasons for the association with acetaminophen use are unclear, given that acetaminophen has very weak anti-inflammatory effects. Springer Science+Business Media B.V., 2011 Aspirin nationallicence NSAIDs nationallicence Breast cancer nationallicence Incidence nationallicence Epidemiology nationallicence Bosco Jaclyn Section of Geriatrics, Department of Medicine, Boston University School of Medicine, Boston, MA, USA aut Palmer Julie Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, 02215, Boston, MA, USA aut Boggs Deborah Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, 02215, Boston, MA, USA aut Hatch Elizabeth Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA aut Rosenberg Lynn Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, 02215, Boston, MA, USA aut Cancer Causes & Control Springer Netherlands 22/11(2011-11-01), 1553-1561 0957-5243 22:11<1553 2011 22 10552 https://doi.org/10.1007/s10552-011-9832-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9832-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bosco Jaclyn Section of Geriatrics, Department of Medicine, Boston University School of Medicine, Boston, MA, USA aut NATIONALLICENCE 700 1- Palmer Julie Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, 02215, Boston, MA, USA aut NATIONALLICENCE 700 1- Boggs Deborah Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, 02215, Boston, MA, USA aut NATIONALLICENCE 700 1- Hatch Elizabeth Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA aut NATIONALLICENCE 700 1- Rosenberg Lynn Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, 02215, Boston, MA, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/11(2011-11-01), 1553-1561 0957-5243 22:11<1553 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer