caa a22 4500 445316276 CHVBK 20180317142648.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s10552-011-9825-5 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9825-5 Gestational diabetes and risk of incident primary cancer: a large historical cohort study in Israel [Elektronische Daten] [Tal Sella, Gabriel Chodick, Micha Barchana, Anthony Heymann, Avi Porath, Ehud Kokia, Varda Shalev] Purpose: Gestational diabetes mellitus (GDM), a state of glucose intolerance associated with pregnancy, is increasing in prevalence. Data regarding the cancer risk associated with GDM are sparse and limited to cancers of the breast and pancreas. This study was conducted to examine the risk of incident overall and site-specific malignancies associated with prior GDM in a historical cohort of women in a large health maintenance organization in Israel. Methods: All pregnant women aged 15-50years who underwent 50-g glucose challenge tests between 13 March 1995 and 27 May 2009, without history of malignancy, diabetes, and infertility, were included. Clinical and demographic parameters at index date including age, socioeconomic level, BMI, and parity were collected. Diagnosis of gestational diabetes was based on the 100-g oral glucose tolerance test using Carpenter and Coustan criteria. Cancer diagnoses were obtained from the Israel Cancer Register through linkage data. Results: Among the 185,315 women who had undergone glucose challenge during the study period, 11,264 (6.1%) were diagnosed with GDM. During a total follow-up period of 1.05 million person-years (mean=5.19±3.9, median=4.3), 2,034 incident cases of cancer were identified. GDM was associated with a hazard ratio (HR) of 7.06 (95% CI: 1.69-29.45) for pancreatic cancer (nine cases) and a HR of 1.70 (95% CI: 0.97-2.99) for hematological malignancies (177 cases). The association between GDM and hematological malignancies was limited to women with 5 or more years of follow-up (HR=4.53; 95% CI: 1.81-11.31). Conclusion: GDM is associated with an increased risk of pancreatic cancer and hematologic malignancies. Springer Science+Business Media B.V., 2011 Gestational diabetes mellitus nationallicence Cancer risk nationallicence Pancreatic cancer nationallicence Lymphoma nationallicence GDM : Gestational diabetes mellitus nationallicence DM : Diabetes mellitus nationallicence GCT : Glucose challenge test nationallicence OGTT : Oral glucose tolerance test nationallicence HMO : Health maintenance organization nationallicence MHS : Maccabi healthcare services nationallicence NHL : Non-hodgkin's lymphoma nationallicence AML : Acute myeloid leukemia nationallicence Sella Tal Medical Division, Maccabi Healthcare Services, 27 Ha'Mered Street, 68125, Tel Aviv, Israel aut Chodick Gabriel Medical Division, Maccabi Healthcare Services, 27 Ha'Mered Street, 68125, Tel Aviv, Israel aut Barchana Micha Israel National Cancer Registry, Ministry of Health, Jerusalem, Israel aut Heymann Anthony Medical Division, Maccabi Healthcare Services, 27 Ha'Mered Street, 68125, Tel Aviv, Israel aut Porath Avi Medical Division, Maccabi Healthcare Services, 27 Ha'Mered Street, 68125, Tel Aviv, Israel aut Kokia Ehud Medical Division, Maccabi Healthcare Services, 27 Ha'Mered Street, 68125, Tel Aviv, Israel aut Shalev Varda Medical Division, Maccabi Healthcare Services, 27 Ha'Mered Street, 68125, Tel Aviv, Israel aut Cancer Causes & Control Springer Netherlands 22/11(2011-11-01), 1513-1520 0957-5243 22:11<1513 2011 22 10552 https://doi.org/10.1007/s10552-011-9825-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9825-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sella Tal Medical Division, Maccabi Healthcare Services, 27 Ha'Mered Street, 68125, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Chodick Gabriel Medical Division, Maccabi Healthcare Services, 27 Ha'Mered Street, 68125, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Barchana Micha Israel National Cancer Registry, Ministry of Health, Jerusalem, Israel aut NATIONALLICENCE 700 1- Heymann Anthony Medical Division, Maccabi Healthcare Services, 27 Ha'Mered Street, 68125, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Porath Avi Medical Division, Maccabi Healthcare Services, 27 Ha'Mered Street, 68125, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Kokia Ehud Medical Division, Maccabi Healthcare Services, 27 Ha'Mered Street, 68125, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Shalev Varda Medical Division, Maccabi Healthcare Services, 27 Ha'Mered Street, 68125, Tel Aviv, Israel aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/11(2011-11-01), 1513-1520 0957-5243 22:11<1513 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer