caa a22 4500 44531821X CHVBK 20180317142654.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10126-011-9371-x doi (NATIONALLICENCE)springer-10.1007/s10126-011-9371-x Linkage Mapping of Toll-Like Receptors (TLRs) in Japanese Flounder, Paralichthys olivaceus [Elektronische Daten] [Seong Hwang, Kanako Fuji, Tomokazu Takano, Takashi Sakamoto, Hidehiro Kondo, Ikuo Hirono, Takashi Aoki] Toll-like receptors (TLRs) are responsible for the recognition of specific pathogen-associated molecular patterns and consequently activate signal pathways leading to inflammatory and interferon responses. The region surrounding several TLRs was previously found to be associated with resistance to specific disease. Hence, we determined the location of 11 TLRs in Japanese flounder (Paralichthys olivaceus) using polymorphic microsatellite markers. TLR1 and TLR3 were located on linkage group (LG) 21 and 7, respectively. Membrane TLR5 and soluble TLR5 were mapped to LG22. TLR7 and TLR8 were mapped to LG3. TLR9 was found on LG1 and TLR14 and TLR21 were located on the same linkage group, LG10. TLR22 was found on LG8. Interestingly, TLR2 was mapped with the previously reported Poli9-8TUF microsatellite marker which is tightly associated with lymphocystis virus disease resistance. Therefore, TLR2 is a candidate gene for resistance to lymphocystis disease. These results imply that the location of a TLR associated with a particular disease may be valuable for the research on the relationship between host immune response and disease resistance. Springer Science+Business Media, LLC, 2011 Toll-like receptors (TLRs) nationallicence Paralichthys olivaceus nationallicence Linkage map nationallicence Microsatellite marker nationallicence Hwang Seong Laboratory of Genome Science, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato-ku, 108-8477, Tokyo, Japan aut Fuji Kanako Faculty of Marine Science, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato-ku, 108-8477, Tokyo, Japan aut Takano Tomokazu Laboratory of Genome Science, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato-ku, 108-8477, Tokyo, Japan aut Sakamoto Takashi Faculty of Marine Science, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato-ku, 108-8477, Tokyo, Japan aut Kondo Hidehiro Laboratory of Genome Science, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato-ku, 108-8477, Tokyo, Japan aut Hirono Ikuo Laboratory of Genome Science, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato-ku, 108-8477, Tokyo, Japan aut Aoki Takashi Laboratory of Genome Science, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato-ku, 108-8477, Tokyo, Japan aut Marine Biotechnology Springer-Verlag 13/6(2011-12-01), 1086-1091 1436-2228 13:6<1086 2011 13 10126 https://doi.org/10.1007/s10126-011-9371-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10126-011-9371-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hwang Seong Laboratory of Genome Science, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato-ku, 108-8477, Tokyo, Japan aut NATIONALLICENCE 700 1- Fuji Kanako Faculty of Marine Science, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato-ku, 108-8477, Tokyo, Japan aut NATIONALLICENCE 700 1- Takano Tomokazu Laboratory of Genome Science, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato-ku, 108-8477, Tokyo, Japan aut NATIONALLICENCE 700 1- Sakamoto Takashi Faculty of Marine Science, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato-ku, 108-8477, Tokyo, Japan aut NATIONALLICENCE 700 1- Kondo Hidehiro Laboratory of Genome Science, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato-ku, 108-8477, Tokyo, Japan aut NATIONALLICENCE 700 1- Hirono Ikuo Laboratory of Genome Science, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato-ku, 108-8477, Tokyo, Japan aut NATIONALLICENCE 700 1- Aoki Takashi Laboratory of Genome Science, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato-ku, 108-8477, Tokyo, Japan aut NATIONALLICENCE 773 0- Marine Biotechnology Springer-Verlag 13/6(2011-12-01), 1086-1091 1436-2228 13:6<1086 2011 13 10126 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer