caa a22 4500 445318503 CHVBK 20180317142655.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10126-010-9337-4 doi (NATIONALLICENCE)springer-10.1007/s10126-010-9337-4 Terpenes from the Red Alga Sphaerococcus coronopifolius Inhibit the Settlement of Barnacles [Elektronische Daten] [Veronica Piazza, Vassilios Roussis, Francesca Garaventa, Giuliano Greco, Vangelis Smyrniotopoulos, Constantinos Vagias, Marco Faimali] In this study, we screened eight terpenes isolated from the organic extract of Sphaerococcus coronopifolius for their antifouling activity in order to find possible new sources of non-toxic or less toxic bioactive antifoulants. The anti-settlement activity (EC50) and the degree of toxicity (LC50) of S. coronopifolius metabolites was evaluated using larvae of the cirriped crustacean Amphibalanus (Balanus) amphitrite (cyprids and nauplii) as model organism. For five of eight tested metabolites EC50 was lower than 5mg/L. The most promising results were observed for bromosphaerol (3), which expressed an EC50 value of 0.23mg/L, in combination with low toxicity levels (LC50 > 100mg/L). The therapeutic ratio—an index used to estimate whether settlement inhibition is due to toxicity or other mechanisms—is also calculated and discussed. Springer Science+Business Media, LLC, 2010 Antifouling nationallicence Marine natural products nationallicence Barnacle nationallicence Sphaerococcus coronopifolius nationallicence Piazza Veronica Institute of Marine Science (ISMAR) CNR, via De Marini 6, 16149, Genoa, Italy aut Roussis Vassilios Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, 15771, Athens, Greece aut Garaventa Francesca Institute of Marine Science (ISMAR) CNR, via De Marini 6, 16149, Genoa, Italy aut Greco Giuliano Institute of Marine Science (ISMAR) CNR, via De Marini 6, 16149, Genoa, Italy aut Smyrniotopoulos Vangelis Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, 15771, Athens, Greece aut Vagias Constantinos Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, 15771, Athens, Greece aut Faimali Marco Institute of Marine Science (ISMAR) CNR, via De Marini 6, 16149, Genoa, Italy aut Marine Biotechnology Springer-Verlag 13/4(2011-08-01), 764-772 1436-2228 13:4<764 2011 13 10126 https://doi.org/10.1007/s10126-010-9337-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10126-010-9337-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Piazza Veronica Institute of Marine Science (ISMAR) CNR, via De Marini 6, 16149, Genoa, Italy aut NATIONALLICENCE 700 1- Roussis Vassilios Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, 15771, Athens, Greece aut NATIONALLICENCE 700 1- Garaventa Francesca Institute of Marine Science (ISMAR) CNR, via De Marini 6, 16149, Genoa, Italy aut NATIONALLICENCE 700 1- Greco Giuliano Institute of Marine Science (ISMAR) CNR, via De Marini 6, 16149, Genoa, Italy aut NATIONALLICENCE 700 1- Smyrniotopoulos Vangelis Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, 15771, Athens, Greece aut NATIONALLICENCE 700 1- Vagias Constantinos Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, 15771, Athens, Greece aut NATIONALLICENCE 700 1- Faimali Marco Institute of Marine Science (ISMAR) CNR, via De Marini 6, 16149, Genoa, Italy aut NATIONALLICENCE 773 0- Marine Biotechnology Springer-Verlag 13/4(2011-08-01), 764-772 1436-2228 13:4<764 2011 13 10126 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer