caa a22 4500 445318910 CHVBK 20180317142657.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10126-010-9349-0 doi (NATIONALLICENCE)springer-10.1007/s10126-010-9349-0 Anti-protease and Immunomodulatory Activities of Bacteria Associated with Caribbean Sponges [Elektronische Daten] [Paula Tabares, Sheila Pimentel-Elardo, Tanja Schirmeister, Thomas Hünig, Ute Hentschel] Marine sponges and their associated bacteria have been proven to be a rich source of novel secondary metabolites with therapeutic usefulness in cancer, infection, and autoimmunity. In this study, 79 strains belonging to 20 genera of the order Actinomycetales and seven strains belonging to two genera of the order Sphingomonadales were cultivated from 18 different Caribbean sponges and identified by 16S rRNA gene sequencing. Seven of these strains are likely to represent novel species. Crude extracts from selected strains were found to exhibit protease inhibition against cathepsins B and L, rhodesain, and falcipain-2 as well as immunomodulatory activities such as induction of cytokine release by human peripheral blood mononuclear cells. These results highlight the significance of marine sponge-associated bacteria to produce bioactive secondary metabolites with therapeutic potential in the treatment of infectious diseases and disorders of the immune system. Springer Science+Business Media, LLC, 2011 Actinomycetes nationallicence Sphingomonads nationallicence Marine sponge nationallicence Anti-protease nationallicence Immunomodulatory nationallicence Phylogenetic analysis nationallicence Tabares Paula Julius-von-Sachs-Institute for Biological Sciences, University of Würzburg, Julius-von-Sachs-Platz 3, 97082, Würzburg, Germany aut Pimentel-Elardo Sheila Julius-von-Sachs-Institute for Biological Sciences, University of Würzburg, Julius-von-Sachs-Platz 3, 97082, Würzburg, Germany aut Schirmeister Tanja Institute for Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, 97074, Würzburg, Germany aut Hünig Thomas Institute for Virology and Immunobiology, University of Würzburg, Versbacherstr. 7, 97078, Würzburg, Germany aut Hentschel Ute Julius-von-Sachs-Institute for Biological Sciences, University of Würzburg, Julius-von-Sachs-Platz 3, 97082, Würzburg, Germany aut Marine Biotechnology Springer-Verlag 13/5(2011-10-01), 883-892 1436-2228 13:5<883 2011 13 10126 https://doi.org/10.1007/s10126-010-9349-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10126-010-9349-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tabares Paula Julius-von-Sachs-Institute for Biological Sciences, University of Würzburg, Julius-von-Sachs-Platz 3, 97082, Würzburg, Germany aut NATIONALLICENCE 700 1- Pimentel-Elardo Sheila Julius-von-Sachs-Institute for Biological Sciences, University of Würzburg, Julius-von-Sachs-Platz 3, 97082, Würzburg, Germany aut NATIONALLICENCE 700 1- Schirmeister Tanja Institute for Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, 97074, Würzburg, Germany aut NATIONALLICENCE 700 1- Hünig Thomas Institute for Virology and Immunobiology, University of Würzburg, Versbacherstr. 7, 97078, Würzburg, Germany aut NATIONALLICENCE 700 1- Hentschel Ute Julius-von-Sachs-Institute for Biological Sciences, University of Würzburg, Julius-von-Sachs-Platz 3, 97082, Würzburg, Germany aut NATIONALLICENCE 773 0- Marine Biotechnology Springer-Verlag 13/5(2011-10-01), 883-892 1436-2228 13:5<883 2011 13 10126 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer