caa a22 4500 445321083 CHVBK 20180317142704.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10534-010-9376-3 doi (NATIONALLICENCE)springer-10.1007/s10534-010-9376-3 Chronic beryllium disease: an updated model interaction between innate and acquired immunity [Elektronische Daten] [Richard Sawyer, Lisa Maier] During the last decade, there have been concerted efforts to reduce beryllium (Be) exposure in the workplace and thereby reduce potential cases of this occupational lung disorder. Despite these efforts, it is estimated that there are at least one million Be-exposed individuals in the U.S. who are potentially at risk for developing chronic beryllium disease (CBD). Previously, we reviewed the current CBD literature and proposed that CBD represents a model interaction between innate and acquired immunity (Sawyer et al., Int Immunopharmacol 2:249-261, 2002). We closed this review with a section on "future directions” that identified key gaps in our understanding of the pathogenesis of CBD. In the intervening period, progress has been made to fill in some of these gaps, and the current review will provide an update on that progress. Based on recent findings, we provide a new hypothesis to explain how Be drives sustained chronic inflammation and granuloma formation in CBD leading to progressive compromised lung function in CBD patients. This paradigm has direct implications for our understanding of the development of an immune response to Be, but is also likely applicable to other immune-mediated lung diseases of known and unknown etiology. Springer Science+Business Media, LLC., 2010 Beryllium nationallicence Chronic beryllium disease nationallicence Granuloma nationallicence Innate immunity nationallicence Acquired immunity nationallicence Sawyer Richard Asthma, Allergy and Inflammation Branch, Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Disease, National Institutes of Health, 6610 Rockledge Drive, Bethesda, MD, USA aut Maier Lisa Robert H. Hollis Laboratory of Environmental and Occupational Health Sciences, Division of Environmental and Occupational Health Science, Department of Medicine, National Jewish Health, Denver, CO, USA aut BioMetals Springer Netherlands 24/1(2011-02-01), 1-17 0966-0844 24:1<1 2011 24 10534 https://doi.org/10.1007/s10534-010-9376-3 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10534-010-9376-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sawyer Richard Asthma, Allergy and Inflammation Branch, Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Disease, National Institutes of Health, 6610 Rockledge Drive, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Maier Lisa Robert H. Hollis Laboratory of Environmental and Occupational Health Sciences, Division of Environmental and Occupational Health Science, Department of Medicine, National Jewish Health, Denver, CO, USA aut NATIONALLICENCE 773 0- BioMetals Springer Netherlands 24/1(2011-02-01), 1-17 0966-0844 24:1<1 2011 24 10534 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer