caa a22 4500 445321113 CHVBK 20180317142704.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10534-010-9391-4 doi (NATIONALLICENCE)springer-10.1007/s10534-010-9391-4 Does high serum iron level induce low bone mass in sickle cell anemia ? [Elektronische Daten] [Mir Sadat-Ali, Osama Sultan, Haifa Al-Turki, Abdulmohsen AlElq] Iron overload is quite common in patients suffering from hemoglobinopathies causing arthropathies, endocrinal affection and neuropathies. Recently low bone mass was added to the list of complications. This study is conducted to find any correlation between serum iron level and low bone mass in sickle cell anemia (SCA). Patients ≥18 years of age with sickle cell anemia, who attended outpatient clinics or admitted to King Fahd University Hospital, Al Khobar, Saudi Arabia,between 1st September 2006 and August 2007 were the subjects of this study. Patients age and sex were documented and body mass index was calculated. Apart from routine hematological tests, serum ferritin, serum Iron level, total estradiol, testosterone level was done. Bone mineral density measurement was done using dual energy X-ray absorptiometry (DEXA) at upper femur and lumbar spine. The data of 100 patients was analyzed, 48 males and 52 females. The mean age was 27.5±6.1years. In 64 patients (32 males and 32 females) serum iron level was 319.35μg/dl and the mean serum ferritin level in males and females was within the normal range. Sixty-eight percent of females and 71.8% of males patients in whom serum iron was high had lower bone mass P=<0.001. Our study shows that SCA patients in whom serum iron level was higher than normal effected bone mass. Further studies are needed to confirm this as a cause of osteoporosis in SCA patients. Springer Science+Business Media, LLC., 2010 Low bone mass nationallicence Serum iron level nationallicence Sickle cell anemia nationallicence Osteoporosis nationallicence Sadat-Ali Mir Department of Orthopaedic Surgery, College of Medicine, University of Dammam, Dammam, Saudi Arabia aut Sultan Osama Department of Internal Medicine, College of Medicine, University of Dammam, Dammam, Saudi Arabia aut Al-Turki Haifa Department of Obstetrics and Gynecology, College of Medicine, University of Dammam, Dammam, Saudi Arabia aut AlElq Abdulmohsen Department of Internal Medicine, College of Medicine, University of Dammam, Dammam, Saudi Arabia aut BioMetals Springer Netherlands 24/1(2011-02-01), 19-22 0966-0844 24:1<19 2011 24 10534 https://doi.org/10.1007/s10534-010-9391-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10534-010-9391-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sadat-Ali Mir Department of Orthopaedic Surgery, College of Medicine, University of Dammam, Dammam, Saudi Arabia aut NATIONALLICENCE 700 1- Sultan Osama Department of Internal Medicine, College of Medicine, University of Dammam, Dammam, Saudi Arabia aut NATIONALLICENCE 700 1- Al-Turki Haifa Department of Obstetrics and Gynecology, College of Medicine, University of Dammam, Dammam, Saudi Arabia aut NATIONALLICENCE 700 1- AlElq Abdulmohsen Department of Internal Medicine, College of Medicine, University of Dammam, Dammam, Saudi Arabia aut NATIONALLICENCE 773 0- BioMetals Springer Netherlands 24/1(2011-02-01), 19-22 0966-0844 24:1<19 2011 24 10534 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer