caa a22 4500 445321261 CHVBK 20180317142704.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10534-011-9467-9 doi (NATIONALLICENCE)springer-10.1007/s10534-011-9467-9 Metal chelation therapy in rheumathoid arthritis: a case report [Elektronische Daten] Successful management of rheumathoid arthritis by metal chelation therapy [Fabrizia Bamonti, Alessandro Fulgenzi, Cristina Novembrino, Maria Ferrero] Toxic metals are involved in the pathogenesis of some neurodegenerative and vascular diseases and are known to impair the immune system functions. We report here the case of a patient affected by heavy metal intoxication, who had developed an autoimmune disease. There was evidence of aluminium, cadmium and lead intoxication in a 63-year old Italian woman affected by rheumatoid arthritis (RA). We treated the patient with calcium disodium edetate (EDTA) once a week for a year in order to remove traces of heavy metal intoxication. Oxidative status profile was carried out at the beginning and after 6months' EDTA chelation. At the end of the treatment, the patient did not show any signs of metal intoxication, RA symptoms and oxidative status improved. Springer Science+Business Media, LLC., 2011 Chelation therapy nationallicence Rheumathoid arthritis nationallicence EDTA nationallicence Metal intoxication nationallicence EDTA : Calcium disodium edetate nationallicence ROS : Reactive oxygen species nationallicence GSH : Reduced form of glutathione nationallicence GSSG : Oxidized form of glutathione nationallicence TAC : Total antioxidant capacity nationallicence Bamonti Fabrizia Dipartimento di Scienze Mediche, Università di Milano, Fondazione IRCCS Ospedale Policlinico, Mangiagalli, Regina Elena, Via F. Sforza 35, Milan, Italy aut Fulgenzi Alessandro Dipartimento di Morfologia Umana e Scienze Biomediche Città Studi, Università di Milano, Via Mangiagalli 31, 20133, Milan, Italy aut Novembrino Cristina Dipartimento di Scienze Mediche, Università di Milano, Fondazione IRCCS Ospedale Policlinico, Mangiagalli, Regina Elena, Via F. Sforza 35, Milan, Italy aut Ferrero Maria Dipartimento di Morfologia Umana e Scienze Biomediche Città Studi, Università di Milano, Via Mangiagalli 31, 20133, Milan, Italy aut BioMetals Springer Netherlands 24/6(2011-12-01), 1093-1098 0966-0844 24:6<1093 2011 24 10534 https://doi.org/10.1007/s10534-011-9467-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10534-011-9467-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bamonti Fabrizia Dipartimento di Scienze Mediche, Università di Milano, Fondazione IRCCS Ospedale Policlinico, Mangiagalli, Regina Elena, Via F. Sforza 35, Milan, Italy aut NATIONALLICENCE 700 1- Fulgenzi Alessandro Dipartimento di Morfologia Umana e Scienze Biomediche Città Studi, Università di Milano, Via Mangiagalli 31, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Novembrino Cristina Dipartimento di Scienze Mediche, Università di Milano, Fondazione IRCCS Ospedale Policlinico, Mangiagalli, Regina Elena, Via F. Sforza 35, Milan, Italy aut NATIONALLICENCE 700 1- Ferrero Maria Dipartimento di Morfologia Umana e Scienze Biomediche Città Studi, Università di Milano, Via Mangiagalli 31, 20133, Milan, Italy aut NATIONALLICENCE 773 0- BioMetals Springer Netherlands 24/6(2011-12-01), 1093-1098 0966-0844 24:6<1093 2011 24 10534 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer