caa a22 4500 445321458 CHVBK 20180317142705.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10534-011-9431-8 doi (NATIONALLICENCE)springer-10.1007/s10534-011-9431-8 Nevitt Tracy Department of Pharmacology and Cancer Biology, Duke University School of Medicine, 27710, Durham, NC, USA aut War-Fe-re: iron at the core of fungal virulence and host immunity [Elektronische Daten] [Tracy Nevitt] Iron acquisition is a bona fide virulence determinant. The successful colonization of the mammalian host requires that microorganisms overcome the Fe aridity of this milieu in which the levels of circulating Fe are maintained exceedingly low both through the compartmentalization of this nutrient within cells as well as the tight binding of Fe to host circulating proteins and ligands. Microbes notoriously employ multiple strategies for high affinity Fe acquisition from the host that rely either on the expression of receptors for host Fe-binding proteins and ligands, its reduction by cell surface reductases or the utilization of siderophores, small organic molecules with very high affinity for Fe3+. This review will discuss the multiple mechanisms deployed by fungal pathogens in Fe acquisition focusing on the role of siderophore utilization in virulence as well as host immune strategies of iron withholding and emerging clinical evidence that human disorders of Fe homeostasis can act as modifiers of infectious disease. Springer Science+Business Media, LLC., 2011 Fungal pathogenesis nationallicence Iron nationallicence Siderophores nationallicence Hereditary hemochromatosis nationallicence BioMetals Springer Netherlands 24/3(2011-06-01), 547-558 0966-0844 24:3<547 2011 24 10534 https://doi.org/10.1007/s10534-011-9431-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10534-011-9431-8 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Nevitt Tracy Department of Pharmacology and Cancer Biology, Duke University School of Medicine, 27710, Durham, NC, USA aut NATIONALLICENCE 773 0- BioMetals Springer Netherlands 24/3(2011-06-01), 547-558 0966-0844 24:3<547 2011 24 10534 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer