caa a22 4500 445321466 CHVBK 20180317142705.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10534-011-9429-2 doi (NATIONALLICENCE)springer-10.1007/s10534-011-9429-2 Intestinal iron absorption during suckling in mammals [Elektronische Daten] [David Frazer, Deepak Darshan, Gregory Anderson] The maintenance of appropriate iron levels is important for mammalian health, particularly during the rapid growth period following birth. Too little iron can lead to irreversible damage to the developing central nervous system and too much iron at this point can have adverse long term consequences, possibly due to excessive free radical production. In order to maintain iron levels, intestinal iron absorption is very efficient in young mammals, such that almost all of the iron in breast milk is utilized. However this high level of absorption is unable to be down regulated in response to excess iron as it can be in adults, implying that different regulatory processes are involved during suckling. Various mechanisms have been proposed to explain this high absorption, including enhanced expression of the proteins involved in iron absorption in adults (particularly DMT1 and ferroportin), non-specific uptake via pinocytosis, and the uptake of lactoferrin bound iron by the lactoferrin receptor. However, at present the precise mechanism is unclear. It is possible that all of these components contribute to the high intestinal iron absorption seen during suckling, or a novel, as yet undescribed, mechanism could be involved. This review summarises the evidence for and against each of the mechanisms described above and highlights how little is known about iron homeostasis in this vital stage of development. Springer Science+Business Media, LLC., 2011 Iron absorption nationallicence Suckling nationallicence Ferroportin nationallicence Lactoferrin nationallicence Pinocytosis nationallicence Frazer David Iron Metabolism Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Herston, 4006, Brisbane, QLD, Australia aut Darshan Deepak Iron Metabolism Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Herston, 4006, Brisbane, QLD, Australia aut Anderson Gregory Iron Metabolism Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Herston, 4006, Brisbane, QLD, Australia aut BioMetals Springer Netherlands 24/3(2011-06-01), 567-574 0966-0844 24:3<567 2011 24 10534 https://doi.org/10.1007/s10534-011-9429-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10534-011-9429-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Frazer David Iron Metabolism Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Herston, 4006, Brisbane, QLD, Australia aut NATIONALLICENCE 700 1- Darshan Deepak Iron Metabolism Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Herston, 4006, Brisbane, QLD, Australia aut NATIONALLICENCE 700 1- Anderson Gregory Iron Metabolism Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Herston, 4006, Brisbane, QLD, Australia aut NATIONALLICENCE 773 0- BioMetals Springer Netherlands 24/3(2011-06-01), 567-574 0966-0844 24:3<567 2011 24 10534 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer