caa a22 4500 445321652 CHVBK 20180317142706.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10534-011-9412-y doi (NATIONALLICENCE)springer-10.1007/s10534-011-9412-y Interactive effect of arsenic and fluoride on cardio-respiratory disorders in male rats: possible role of reactive oxygen species [Elektronische Daten] [S. Flora, Vidhu Pachauri, Megha Mittal, Deo Kumar] Epidemiological evidence demonstrates positive correlation between environmental and occupational arsenic or fluoride exposure and risk to various cardio-respiratory disorders. Arsenic-exposure has been associated with atherosclerosis, hypertension, cerebrovascular diseases, ischemic heart disease, and peripheral vascular disorders, whereas Fluoride-exposure manifests cardiac irregularities and low blood pressure (BP). Present study aims to study the combined effects of these toxicants on various cardio-respiratory variables in male rats. Single intravenous (i.v.) dose of arsenic (1, 5, 10mg/kg) or fluoride (5, 10, 20, 36.5mg/kg) either alone or in combination were administered. Individual exposure to arsenic or fluoride led to a significant depletion of mean arterial pressure, heart rate (HR), respiration rate and neuromuscular (NM) transmission in a dose-dependent manner. These changes were accompanied by increased levels of blood reactive oxygen species (ROS) and decreased glutathione (GSH) concentrations. An increase in the blood acetyl cholinesterase (AChE) activity was observed in both arsenic or fluoride exposed rats. These changes were significantly more pronounced in arsenic-exposed animals than in fluoride. During combined exposure to arsenic (5mg/kg)+fluoride (20mg/kg) or arsenic (10mg/kg)+fluoride (36.5mg/kg) the toxic effects were more pronounced compared to individual toxicities of arsenic or fluoride alone. However, combined exposure to arsenic (5mg/kg)+fluoride (36.5mg/kg) resulted in antagonistic effects on variables suggestive of altered cardio-respiratory function and oxidative stress. The results from the present study suggest that arsenic or fluoride individually demonstrate cardio-respiratory failure at all doses whereas during combination exposure these toxins show variable toxicities; both synergistic and antagonistic effects depending upon the dose. Moreover, it may be concluded that arsenic and/or fluoride cardio-respiratory toxicity may be mediated via oxidative stress. However, these results are new in the discipline thus requires further exploration. Springer Science+Business Media, LLC., 2011 Cardio-respiration nationallicence Oxidative stress nationallicence Neuromuscular transmission nationallicence Heart rate nationallicence Respiration rate nationallicence Arterial pressure nationallicence Arsenic nationallicence Fluoride nationallicence As : Arsenic nationallicence F : Fluoride nationallicence NM : Neuromuscular nationallicence ROS : Reactive oxygen species nationallicence GSH : Reduced glutathione nationallicence AChE : Acetyl cholinesterase nationallicence SBP : Systolic BP nationallicence MAP : Mean arterial pressure nationallicence Flora S. Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, 474 002, Gwalior, India aut Pachauri Vidhu Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, 474 002, Gwalior, India aut Mittal Megha Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, 474 002, Gwalior, India aut Kumar Deo Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, 474 002, Gwalior, India aut BioMetals Springer Netherlands 24/4(2011-08-01), 615-628 0966-0844 24:4<615 2011 24 10534 https://doi.org/10.1007/s10534-011-9412-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10534-011-9412-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Flora S. Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, 474 002, Gwalior, India aut NATIONALLICENCE 700 1- Pachauri Vidhu Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, 474 002, Gwalior, India aut NATIONALLICENCE 700 1- Mittal Megha Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, 474 002, Gwalior, India aut NATIONALLICENCE 700 1- Kumar Deo Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, 474 002, Gwalior, India aut NATIONALLICENCE 773 0- BioMetals Springer Netherlands 24/4(2011-08-01), 615-628 0966-0844 24:4<615 2011 24 10534 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer