caa a22 4500 445321660 CHVBK 20180317142706.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10534-011-9414-9 doi (NATIONALLICENCE)springer-10.1007/s10534-011-9414-9 Antileukemic activity and cellular effects of rhodium(III) crown thiaether complexes [Elektronische Daten] [Ruth Bieda, Igor Kitanovic, Hamed Alborzinia, Andreas Meyer, Ingo Ott, Stefan Wölfl, William Sheldrick] The cytostatic properties of novel rhodium(III) thiacrown ether complexes [RhCl(LL)([9]aneS3)]n+ with either aromatic κ2 N ligands (n=2) or anionic chelate ligands (n=1) have been investigated for the human cancer cell lines HT-29 and MCF-7 and for immortalized HEK-293 cells. Taken together with literature IC50 values for analogous complexes with polypyridyl ligands or 1,4-dithiane, the in vitro assays indicate that dicationic complexes with soft κ2 N (imino) or κ2 S (thiaether) ligands exhibit significantly higher antiproliferative effects than those with hard κ2 N (amino) ligands. Dicationic complexes are more active than monocationic complexes with similar ligands. Pronounced apoptosis-inducing properties towards Jurkat cells were established for complexes with LL=bpm, dpq, and 1,4-dithiane. The order of activity (bpm>1,4-dithiane>dpq>bpy) contrasts to that observed for adhesive cancer cells (bpm>bpy, 1,4-dithiane>dpq). Necrosis is insignificant in all cases. The percentage of Jurkat cells exhibiting apoptosis after 24 or 48h incubation periods is directly correlated to the percentage of cells exhibiting high levels of reactive oxygen species. As established by online monitoring with a sensor chip system, treatment of MCF-7 cells with the bpm and 1,4-dithiane complexes leads to a significant and permanent concentration-dependent decrease in oxygen consumption and cellular adhesion. Springer Science+Business Media, LLC., 2011 Rhodium nationallicence Thiacrown ether nationallicence Cytotoxicity nationallicence Leukemia nationallicence Apoptosis nationallicence ROS nationallicence Bieda Ruth Lehrstuhl für Analytische Chemie, Ruhr-Universität Bochum, 44780, Bochum, Germany aut Kitanovic Igor Institut für Pharmazie und Molekulare Biotechnologie, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 364, 69120, Heidelberg, Germany aut Alborzinia Hamed Institut für Pharmazie und Molekulare Biotechnologie, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 364, 69120, Heidelberg, Germany aut Meyer Andreas Institut für Pharmazeutische Chemie, Technische Universität Braunschweig, Beethovenstraße 55, 38106, Braunschweig, Germany aut Ott Ingo Institut für Pharmazeutische Chemie, Technische Universität Braunschweig, Beethovenstraße 55, 38106, Braunschweig, Germany aut Wölfl Stefan Institut für Pharmazie und Molekulare Biotechnologie, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 364, 69120, Heidelberg, Germany aut Sheldrick William Lehrstuhl für Analytische Chemie, Ruhr-Universität Bochum, 44780, Bochum, Germany aut BioMetals Springer Netherlands 24/4(2011-08-01), 645-661 0966-0844 24:4<645 2011 24 10534 https://doi.org/10.1007/s10534-011-9414-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10534-011-9414-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bieda Ruth Lehrstuhl für Analytische Chemie, Ruhr-Universität Bochum, 44780, Bochum, Germany aut NATIONALLICENCE 700 1- Kitanovic Igor Institut für Pharmazie und Molekulare Biotechnologie, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 364, 69120, Heidelberg, Germany aut NATIONALLICENCE 700 1- Alborzinia Hamed Institut für Pharmazie und Molekulare Biotechnologie, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 364, 69120, Heidelberg, Germany aut NATIONALLICENCE 700 1- Meyer Andreas Institut für Pharmazeutische Chemie, Technische Universität Braunschweig, Beethovenstraße 55, 38106, Braunschweig, Germany aut NATIONALLICENCE 700 1- Ott Ingo Institut für Pharmazeutische Chemie, Technische Universität Braunschweig, Beethovenstraße 55, 38106, Braunschweig, Germany aut NATIONALLICENCE 700 1- Wölfl Stefan Institut für Pharmazie und Molekulare Biotechnologie, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 364, 69120, Heidelberg, Germany aut NATIONALLICENCE 700 1- Sheldrick William Lehrstuhl für Analytische Chemie, Ruhr-Universität Bochum, 44780, Bochum, Germany aut NATIONALLICENCE 773 0- BioMetals Springer Netherlands 24/4(2011-08-01), 645-661 0966-0844 24:4<645 2011 24 10534 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer