caa a22 4500 445321709 CHVBK 20180317142706.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10534-011-9433-6 doi (NATIONALLICENCE)springer-10.1007/s10534-011-9433-6 Neuroprotective and neurotrophic effects of long term lithium treatment in mouse brain [Elektronische Daten] [Nciri Riadh, Mohamed Allagui, Ezzedine Bourogaa, Christian Vincent, Françoise Croute, Abdelfattah Elfeki] Since the worldwide approval of lithium therapy in 1970, lithium has been used for its anti-manic, antidepressant, and anti-suicidal effects. The last decade has witnessed the following discoveries about its neuroprotective and neurotrophic properties, yet the therapeutic mechanisms at the cellular level remain not-fully defined. We have undertaken the present study to determine if chronic lithium treatment, at therapeutically relevant concentrations, exerts neurotrophic/neuroprotective effects in the mouse brain in vivo. For this purpose, 10months aged mice were fed for 3months on food pellets contained 1g (L1 group) or 2g (L2 group) lithium carbonate/kg, resulting in serum concentrations of 0.4 and 0.8mM, respectively. The evaluation of lipid peroxidation level and the activities of catalase, superoxide-dismutase and glutathione-peroxidase showed that chronic Li administration, at therapeutic doses doesn't induce oxidative stress in brain tissue. No changes in the expression levels of molecular chaperones, namely, the HSP70, and HSP90 heat shock proteins and the GRP94 glucose-regulated protein were detected. Moreover, this treatment has caused (1) an increase in the relative brain weight (2) a delay in the age induced cerebral glucose impairment (3) an enhancement of the neurogenesis in hippocampus and enthorinal cortex highlighted by silver impregnation. Under these experimental conditions, no modifications were observed in expression levels of GSK3 and of its downstream target β-catenin proteins. These results suggested that chronic Li administration, at therapeutic doses, has a neuroprotective/neurotrophic properties and its therapeutic mechanism doesn't implicate GSK3 inactivation. Springer Science+Business Media, LLC., 2011 Lithium nationallicence Brain nationallicence Neuroprotective nationallicence Neurotrophic nationallicence GSK3 nationallicence β-catenin nationallicence Riadh Nciri Laboratoire d'Ecophysiologie Animale, Faculté des Sciences de Sfax, PB 802, 3018, Sfax, Tunisia aut Allagui Mohamed Laboratoire d'Ecophysiologie Animale, Faculté des Sciences de Sfax, PB 802, 3018, Sfax, Tunisia aut Bourogaa Ezzedine Laboratoire d'Ecophysiologie Animale, Faculté des Sciences de Sfax, PB 802, 3018, Sfax, Tunisia aut Vincent Christian Laboratoire de Biologie Cellulaire et Pollution, Faculté de Médecine Toulouse Purpan, Toulouse, France aut Croute Françoise Laboratoire de Biologie Cellulaire et Pollution, Faculté de Médecine Toulouse Purpan, Toulouse, France aut Elfeki Abdelfattah Laboratoire d'Ecophysiologie Animale, Faculté des Sciences de Sfax, PB 802, 3018, Sfax, Tunisia aut BioMetals Springer Netherlands 24/4(2011-08-01), 747-757 0966-0844 24:4<747 2011 24 10534 https://doi.org/10.1007/s10534-011-9433-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10534-011-9433-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Riadh Nciri Laboratoire d'Ecophysiologie Animale, Faculté des Sciences de Sfax, PB 802, 3018, Sfax, Tunisia aut NATIONALLICENCE 700 1- Allagui Mohamed Laboratoire d'Ecophysiologie Animale, Faculté des Sciences de Sfax, PB 802, 3018, Sfax, Tunisia aut NATIONALLICENCE 700 1- Bourogaa Ezzedine Laboratoire d'Ecophysiologie Animale, Faculté des Sciences de Sfax, PB 802, 3018, Sfax, Tunisia aut NATIONALLICENCE 700 1- Vincent Christian Laboratoire de Biologie Cellulaire et Pollution, Faculté de Médecine Toulouse Purpan, Toulouse, France aut NATIONALLICENCE 700 1- Croute Françoise Laboratoire de Biologie Cellulaire et Pollution, Faculté de Médecine Toulouse Purpan, Toulouse, France aut NATIONALLICENCE 700 1- Elfeki Abdelfattah Laboratoire d'Ecophysiologie Animale, Faculté des Sciences de Sfax, PB 802, 3018, Sfax, Tunisia aut NATIONALLICENCE 773 0- BioMetals Springer Netherlands 24/4(2011-08-01), 747-757 0966-0844 24:4<747 2011 24 10534 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer