caa a22 4500 445321741 CHVBK 20180317142706.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10534-011-9424-7 doi (NATIONALLICENCE)springer-10.1007/s10534-011-9424-7 The binding of aluminum to mugineic acid and related compounds as studied by potentiometric titration [Elektronische Daten] [Etsuro Yoshimura, Hicham Kohdr, Satoshi Mori, Robert Hider] The phytosiderophores, mugineic acid (MA) and epi-hydroxymugineic acid (HMA), together with a related compound, nicotianamine (NA), were investigated for their ability to bind Al(III). Potentiometric titration analysis demonstrated that MA and HMA bind Al(III), in contrast to NA which does not under normal physiological conditions. With MA and HMA, in addition to the Al complex (AlL), the protonated (AlLH) and deprotonated (AlLH−1) complexes were identified from an analysis of titration curves, where L denotes the phytosiderophore form in which all the carboxylate functions are ionized. The equilibrium formation constants of the Al(III) phytosiderophore complexes are much smaller than those of the corresponding Fe(III) complexes. The higher selectivity of phytosiderophores for Fe(III) over Al(III) facilitates Fe(III) acquisition in alkaline conditions where free Al(III) levels are higher than free Fe(III) levels. Springer Science+Business Media, LLC., 2011 Aluminum nationallicence Epi-hydroxymugineic acid nationallicence Iron nationallicence Mugineic acid nationallicence Nicotianamine nationallicence Potentiometric titration nationallicence Yoshimura Etsuro Department of Applied Biological Chemistry, The University of Tokyo, Yayoi, Bunkyo-ku, 113-8657, Tokyo, Japan aut Kohdr Hicham Division of Pharmaceutical Science, King's College London, Franklin Wilkins Building, 150 Stamford Street, SE1 9NH, London, UK aut Mori Satoshi Department of Applied Biological Chemistry, The University of Tokyo, Yayoi, Bunkyo-ku, 113-8657, Tokyo, Japan aut Hider Robert Division of Pharmaceutical Science, King's College London, Franklin Wilkins Building, 150 Stamford Street, SE1 9NH, London, UK aut BioMetals Springer Netherlands 24/4(2011-08-01), 723-727 0966-0844 24:4<723 2011 24 10534 https://doi.org/10.1007/s10534-011-9424-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10534-011-9424-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yoshimura Etsuro Department of Applied Biological Chemistry, The University of Tokyo, Yayoi, Bunkyo-ku, 113-8657, Tokyo, Japan aut NATIONALLICENCE 700 1- Kohdr Hicham Division of Pharmaceutical Science, King's College London, Franklin Wilkins Building, 150 Stamford Street, SE1 9NH, London, UK aut NATIONALLICENCE 700 1- Mori Satoshi Department of Applied Biological Chemistry, The University of Tokyo, Yayoi, Bunkyo-ku, 113-8657, Tokyo, Japan aut NATIONALLICENCE 700 1- Hider Robert Division of Pharmaceutical Science, King's College London, Franklin Wilkins Building, 150 Stamford Street, SE1 9NH, London, UK aut NATIONALLICENCE 773 0- BioMetals Springer Netherlands 24/4(2011-08-01), 723-727 0966-0844 24:4<723 2011 24 10534 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer