caa a22 4500 44532175X CHVBK 20180317142706.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10534-011-9407-8 doi (NATIONALLICENCE)springer-10.1007/s10534-011-9407-8 Investigation on the pharmacological profile of antimony(III) complexes with hydroxyquinoline derivatives: anti-trypanosomal activity and cytotoxicity against human leukemia cell lines [Elektronische Daten] [Débora Reis, Mauro Pinto, Elaine Souza-Fagundes, Lucas Rocha, Valéria Pereira, Cristiane Melo, Heloisa Beraldo] Complexes [Sb(QN)2Cl] (1), [Sb(QC)2Cl] (2) and [Sb(QI)2Cl] (3) were obtained with 8-hydroxyquinoline (HQN), 5-chloro-8-hydroxyquinoline (HQC) and 5-chloro-7-iodo-8-hydroxyquinoline (clioquinol, HQI). The quinoline derivatives and their antimony(III) complexes were evaluated for their anti-trypanosomal activity as well as for their cytotoxicity against HL-60 and Jurkat human leukemia cell lines. Upon coordination to antimony(III) the anti-trypanosomal activity of HQC and HQI increases, the highest improvement being observed for complex (3), which was the most active among all studied compounds against both epimastigote and trypomastigote forms of Trypanosoma cruzi. All quinoline derivatives proved to be cytotoxic against both leukemia cell lineages. Upon coordination to antimony(III) the cytotoxicity of HQN improved against Jurkat leukemia cells. While SbCl3 proved to be cytotoxic against HL-60 cells, it was not active against Jurkat cells. However, its coordination to the quinoline derivatives resulted in complexes with significant cytotoxicity against Jurkat cells. Springer Science+Business Media, LLC., 2011 8-Hydroxyquinoline nationallicence 5-Chloro-8-hydroxyquinoline nationallicence 5-Chloro-7-iodo-8-hydroxyquinoline (clioquinol) nationallicence Antimony(III) complexes nationallicence Cytotoxicity nationallicence Leukemia nationallicence Anti-trypanosomal nationallicence Reis Débora Departamento de Química, Universidade Federal de Minas Gerais, 31270-901, Belo Horizonte, MG, Brazil aut Pinto Mauro Departamento de Fisiologia, Universidade Federal de Minas Gerais, 31270-901, Belo Horizonte, MG, Brazil aut Souza-Fagundes Elaine Departamento de Fisiologia, Universidade Federal de Minas Gerais, 31270-901, Belo Horizonte, MG, Brazil aut Rocha Lucas Laboratório de Imunogenética, Departamento de Imunologia, Instituto Aggeu Magalhães - FIOCRUZ, Pernambuco, Brazil aut Pereira Valéria Laboratório de Imunogenética, Departamento de Imunologia, Instituto Aggeu Magalhães - FIOCRUZ, Pernambuco, Brazil aut Melo Cristiane Laboratório de Imunogenética, Departamento de Imunologia, Instituto Aggeu Magalhães - FIOCRUZ, Pernambuco, Brazil aut Beraldo Heloisa Departamento de Química, Universidade Federal de Minas Gerais, 31270-901, Belo Horizonte, MG, Brazil aut BioMetals Springer Netherlands 24/4(2011-08-01), 595-601 0966-0844 24:4<595 2011 24 10534 https://doi.org/10.1007/s10534-011-9407-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10534-011-9407-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Reis Débora Departamento de Química, Universidade Federal de Minas Gerais, 31270-901, Belo Horizonte, MG, Brazil aut NATIONALLICENCE 700 1- Pinto Mauro Departamento de Fisiologia, Universidade Federal de Minas Gerais, 31270-901, Belo Horizonte, MG, Brazil aut NATIONALLICENCE 700 1- Souza-Fagundes Elaine Departamento de Fisiologia, Universidade Federal de Minas Gerais, 31270-901, Belo Horizonte, MG, Brazil aut NATIONALLICENCE 700 1- Rocha Lucas Laboratório de Imunogenética, Departamento de Imunologia, Instituto Aggeu Magalhães - FIOCRUZ, Pernambuco, Brazil aut NATIONALLICENCE 700 1- Pereira Valéria Laboratório de Imunogenética, Departamento de Imunologia, Instituto Aggeu Magalhães - FIOCRUZ, Pernambuco, Brazil aut NATIONALLICENCE 700 1- Melo Cristiane Laboratório de Imunogenética, Departamento de Imunologia, Instituto Aggeu Magalhães - FIOCRUZ, Pernambuco, Brazil aut NATIONALLICENCE 700 1- Beraldo Heloisa Departamento de Química, Universidade Federal de Minas Gerais, 31270-901, Belo Horizonte, MG, Brazil aut NATIONALLICENCE 773 0- BioMetals Springer Netherlands 24/4(2011-08-01), 595-601 0966-0844 24:4<595 2011 24 10534 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer