caa a22 4500 445321814 CHVBK 20180317142706.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10534-011-9452-3 doi (NATIONALLICENCE)springer-10.1007/s10534-011-9452-3 Influence of vanadium supplementation on oxidative stress factors in the muscle of STZ-diabetic rats [Elektronische Daten] [Ozlem Kurt, Tugba Ozden, Nurten Ozsoy, Sevim Tunali, Ayse Can, Nuriye Akev, Refiye Yanardag] In recent years, the role of free radical damage consequent to oxidative stress is widely discussed in diabetic complications. In this aspect, the protection of cell integrity by trace elements is a topic to be investigated. Vanadium is a trace element believed to be important for normal cell function and development. The aim of the present study was to investigate the effect of vanadyl sulfate supplementation on the antioxidant system in the muscle tissue of diabetic rats. Diabetes was induced by intraperitoneal injection of streptozotocin (STZ, 65mg/kg body weight) to male Swiss albino rats. The rats were randomly divided into 4 groups: Group I, control; Group II, vanadyl sulfate control; Group III, STZ-diabetic untreated; Group IV, STZ-diabetic treated with vanadyl sulfate. Vanadyl sulfate (100mg/kg) was given daily by gavage for 60days. At the last day of the experiment, rats were killed, muscle tissues were taken, homogenized in cold saline to make a 10% (w/v) homogenate. Body weights and blood glucose levels were estimated at 0, 30 and 60th days. Antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx), glutathione-S-transferase (GST), as well as carbonic anhydrase (CA), myeloperoxidase (MPO) activities and protein carbonyl content (PCC) were determined in muscle tissue. Vanadyl sulfate administration improved the loss in body weight due to STZ-induced diabetes and decreased the rise in blood glucose levels. It was shown that vanadium supplementation to diabetic rats significantly decrease serum antioxidant enzyme levels, which were significantly raised by diabetes in muscle tissue showing that this trace element could be used as preventive for diabetic complications. Springer Science+Business Media, LLC., 2011 Vanadium nationallicence Antioxidant enzymes nationallicence Muscle nationallicence Diabetes mellitus nationallicence Streptozotocin nationallicence Kurt Ozlem Department of Biochemistry, Faculty of Pharmacy, Istanbul University, 34116, Beyazit-Istanbul, Turkey aut Ozden Tugba Department of Biochemistry, Faculty of Pharmacy, Istanbul University, 34116, Beyazit-Istanbul, Turkey aut Ozsoy Nurten Department of Biochemistry, Faculty of Pharmacy, Istanbul University, 34116, Beyazit-Istanbul, Turkey aut Tunali Sevim Department of Chemistry, Faculty of Engineering, Istanbul University, 34320, Avcilar-Istanbul, Turkey aut Can Ayse Department of Biochemistry, Faculty of Pharmacy, Istanbul University, 34116, Beyazit-Istanbul, Turkey aut Akev Nuriye Department of Biochemistry, Faculty of Pharmacy, Istanbul University, 34116, Beyazit-Istanbul, Turkey aut Yanardag Refiye Department of Chemistry, Faculty of Engineering, Istanbul University, 34320, Avcilar-Istanbul, Turkey aut BioMetals Springer Netherlands 24/5(2011-10-01), 943-949 0966-0844 24:5<943 2011 24 10534 https://doi.org/10.1007/s10534-011-9452-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10534-011-9452-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kurt Ozlem Department of Biochemistry, Faculty of Pharmacy, Istanbul University, 34116, Beyazit-Istanbul, Turkey aut NATIONALLICENCE 700 1- Ozden Tugba Department of Biochemistry, Faculty of Pharmacy, Istanbul University, 34116, Beyazit-Istanbul, Turkey aut NATIONALLICENCE 700 1- Ozsoy Nurten Department of Biochemistry, Faculty of Pharmacy, Istanbul University, 34116, Beyazit-Istanbul, Turkey aut NATIONALLICENCE 700 1- Tunali Sevim Department of Chemistry, Faculty of Engineering, Istanbul University, 34320, Avcilar-Istanbul, Turkey aut NATIONALLICENCE 700 1- Can Ayse Department of Biochemistry, Faculty of Pharmacy, Istanbul University, 34116, Beyazit-Istanbul, Turkey aut NATIONALLICENCE 700 1- Akev Nuriye Department of Biochemistry, Faculty of Pharmacy, Istanbul University, 34116, Beyazit-Istanbul, Turkey aut NATIONALLICENCE 700 1- Yanardag Refiye Department of Chemistry, Faculty of Engineering, Istanbul University, 34320, Avcilar-Istanbul, Turkey aut NATIONALLICENCE 773 0- BioMetals Springer Netherlands 24/5(2011-10-01), 943-949 0966-0844 24:5<943 2011 24 10534 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer