caa a22 4500 445321881 CHVBK 20180317142706.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10534-011-9453-2 doi (NATIONALLICENCE)springer-10.1007/s10534-011-9453-2 Induction of oxidative stress by low doses of lead in human hepatic cell line WRL-68 [Elektronische Daten] [Pablo Hernández-Franco, Martín Silva, Mahara Valverde, Emilio Rojas] Even though the molecular mechanisms by which lead induces toxicity and cancer have been intensely studied for many years, its carcinogenic mechanisms are not well understood yet. Several possible mechanisms have been examined to gain understanding on the carcinogenic properties of lead, which include mitogenesis, alteration of gene expression, and oxidative damage, among others. The aim of the present study was to explore the induction of oxidative damage at low lead concentrations using human embryonic hepatic cells WRL-68. Our results showed induction of reactive oxygen species, changes in the superoxide dismutase and catalase activity, as well as an induction of lipidperoxidation and DNA damage. However, after 5weeks of exposure, these alterations returned to their basal levels. These results taking together indicate that at low concentrations, lead is able to establish an oxidative stress scenario; however under optimal antioxidant defense the oxidative scenario could be abolished through an adaptative process. Springer Science+Business Media, LLC., 2011 Lead nationallicence Oxidative stress nationallicence Catalase nationallicence SOD nationallicence ROS nationallicence DNA damage nationallicence Lipid peroxidation nationallicence Hernández-Franco Pablo Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, 04510, México, DF, México aut Silva Martín Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, 04510, México, DF, México aut Valverde Mahara Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, 04510, México, DF, México aut Rojas Emilio Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, 04510, México, DF, México aut BioMetals Springer Netherlands 24/5(2011-10-01), 951-958 0966-0844 24:5<951 2011 24 10534 https://doi.org/10.1007/s10534-011-9453-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10534-011-9453-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hernández-Franco Pablo Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, 04510, México, DF, México aut NATIONALLICENCE 700 1- Silva Martín Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, 04510, México, DF, México aut NATIONALLICENCE 700 1- Valverde Mahara Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, 04510, México, DF, México aut NATIONALLICENCE 700 1- Rojas Emilio Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, 04510, México, DF, México aut NATIONALLICENCE 773 0- BioMetals Springer Netherlands 24/5(2011-10-01), 951-958 0966-0844 24:5<951 2011 24 10534 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer