caa a22 4500 44532189X CHVBK 20180317142706.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10534-011-9454-1 doi (NATIONALLICENCE)springer-10.1007/s10534-011-9454-1 Manganese accumulation in the CNS and associated pathologies [Elektronische Daten] [Susana Rivera-Mancía, Camilo Ríos, Sergio Montes] Manganese (Mn) is an essential metal for life. It is a key constituent of clue enzymes in the central nervous system, contributing to antioxidant defenses, energetic metabolism, ammonia detoxification, among other important functions. Until now, Mn transport mechanisms are partially understood; however, it is known that it shares some mechanisms of transport with iron. CNS is susceptible to Mn toxicity because it possesses mechanisms that allow Mn entry and favor its accumulation. Cases of occupational Mn exposure have been extensively reported in the literature; however, there are other ways of exposure, such as long-term parental nutrition and liver failure. Manganism and hepatic encephalopathy are the most common pathologies associated with the effects of Mn exposure. Both pathologies are associated with motor and psychiatric disturbances, related in turn to mechanisms of damage such as oxidative stress and neurotransmitters alterations, the dopaminergic system being one of the most affected. Although manganism and Parkinson's disease share some characteristics, they differ in many aspects that are discussed here. The mechanisms for Mn transport and its participation in manganism and hepatic encephalopathy are also considered in this review. It is necessary to find an effective therapeutic strategy to decrease Mn levels in exposed individuals and to treat Mn long term effects. In the case of patients with chronic liver failure it would be worthwhile to test a low-Mn diet in order to ameliorate symptoms of hepatic encephalopathy possibly related to Mn accumulation. Springer Science+Business Media, LLC., 2011 Manganese transport nationallicence Dopamine nationallicence Manganism nationallicence Hepatic encephalopathy nationallicence Oxidative stress nationallicence Rivera-Mancía Susana Neurochemistry Department, National Institute of Neurology and Neurosurgery ‘Manuel Velasco Suárez', Insurgentes Sur 3877, La Fama, Tlalpan, 14269, Mexico City, Mexico aut Ríos Camilo Neurochemistry Department, National Institute of Neurology and Neurosurgery ‘Manuel Velasco Suárez', Insurgentes Sur 3877, La Fama, Tlalpan, 14269, Mexico City, Mexico aut Montes Sergio Neurochemistry Department, National Institute of Neurology and Neurosurgery ‘Manuel Velasco Suárez', Insurgentes Sur 3877, La Fama, Tlalpan, 14269, Mexico City, Mexico aut BioMetals Springer Netherlands 24/5(2011-10-01), 811-825 0966-0844 24:5<811 2011 24 10534 https://doi.org/10.1007/s10534-011-9454-1 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10534-011-9454-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rivera-Mancía Susana Neurochemistry Department, National Institute of Neurology and Neurosurgery ‘Manuel Velasco Suárez', Insurgentes Sur 3877, La Fama, Tlalpan, 14269, Mexico City, Mexico aut NATIONALLICENCE 700 1- Ríos Camilo Neurochemistry Department, National Institute of Neurology and Neurosurgery ‘Manuel Velasco Suárez', Insurgentes Sur 3877, La Fama, Tlalpan, 14269, Mexico City, Mexico aut NATIONALLICENCE 700 1- Montes Sergio Neurochemistry Department, National Institute of Neurology and Neurosurgery ‘Manuel Velasco Suárez', Insurgentes Sur 3877, La Fama, Tlalpan, 14269, Mexico City, Mexico aut NATIONALLICENCE 773 0- BioMetals Springer Netherlands 24/5(2011-10-01), 811-825 0966-0844 24:5<811 2011 24 10534 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer