caa a22 4500 445321946 CHVBK 20180317142706.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10534-011-9445-2 doi (NATIONALLICENCE)springer-10.1007/s10534-011-9445-2 Spectroscopic studies of amphotericin B-Cu2+ complexes [Elektronische Daten] [Mariusz Gagoś, Grzegorz Czernel, Daniel Kamiński, Krzysztof Kostro] The aim of this research is to investigate amphotericin B (AmB)-Cu2+ complexes in aqueous solution at different pH values. Electronic absorption, circular dichroism (CD), Raman and FTIR spectroscopies were used in this study. We found that different concentrations of AmB and Cu2+ ions in solution leads to formation of complexes with stoichiometry of 2:1 and 1:1. The formation of AmB-Cu2+ complexes at physiological pH values is accompanied by changes of the molecular organization of AmB especially disaggregation. These observed effects might be significant from a medical point of view. Springer Science+Business Media, LLC., 2011 Amphotericin B nationallicence Copper complexes nationallicence pH nationallicence Electronic absorption nationallicence CD, Raman and FTIR spectroscopies nationallicence Gagoś Mariusz Department of Biophysics, University of Life Sciences in Lublin, Akademicka 13, 20-950, Lublin, Poland aut Czernel Grzegorz Department of Biophysics, University of Life Sciences in Lublin, Akademicka 13, 20-950, Lublin, Poland aut Kamiński Daniel Department of Chemistry, University of Life Sciences in Lublin, Akademicka 15, 20-950, Lublin, Poland aut Kostro Krzysztof Department of Epizootiology and Clinic of Infectious Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, 20-612, Lublin, Poland aut BioMetals Springer Netherlands 24/5(2011-10-01), 915-922 0966-0844 24:5<915 2011 24 10534 https://doi.org/10.1007/s10534-011-9445-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10534-011-9445-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gagoś Mariusz Department of Biophysics, University of Life Sciences in Lublin, Akademicka 13, 20-950, Lublin, Poland aut NATIONALLICENCE 700 1- Czernel Grzegorz Department of Biophysics, University of Life Sciences in Lublin, Akademicka 13, 20-950, Lublin, Poland aut NATIONALLICENCE 700 1- Kamiński Daniel Department of Chemistry, University of Life Sciences in Lublin, Akademicka 15, 20-950, Lublin, Poland aut NATIONALLICENCE 700 1- Kostro Krzysztof Department of Epizootiology and Clinic of Infectious Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, 20-612, Lublin, Poland aut NATIONALLICENCE 773 0- BioMetals Springer Netherlands 24/5(2011-10-01), 915-922 0966-0844 24:5<915 2011 24 10534 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer