caa a22 4500 445321954 CHVBK 20180317142707.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10534-011-9450-5 doi (NATIONALLICENCE)springer-10.1007/s10534-011-9450-5 Lactoferrin in human tumours: immunohistochemical investigations during more than 25 years [Elektronische Daten] [Giovanni Tuccari, Gaetano Barresi] Lactoferrin (LF) is an iron-binding glycoprotein of the transferrin family, today known to have multifunctional physiological activities. In humans, under normal conditions, LF has been found in blood, mucosal secretions, gastrointestinal fluids, urine and mostly in milk and colostrum. The first pioneering immunohistochemical report about LF distribution in human tissues dated in 1978; successively, many studies have been performed to analyze the LF immunohistochemical pattern in different normal and neoplastic tissues. In this review, we present data from literature concerning the evidence of LF in tumors together with those by us obtained during more than 25 years; the immunohistochemical applications to human neoplastic tissues have been done to investigate the LF pathogenetic role as well as its activity in cancer. After a systematic analysis of LF immunoreactivity in different human districts, a possible explanation for its presence and function has been modulated for each site or tissue, according to experimental evidences obtained either by in vivo as well as by in vitro studies. Springer Science+Business Media, LLC., 2011 Lactoferrin nationallicence Cancer nationallicence Immunohistochemistry nationallicence Research nationallicence Clinical applications nationallicence Tuccari Giovanni Department of Human Pathology, University of Messina, Azienda Ospedaliera Universitaria "Policlinico G.Martino”, Via Consolare Valeria, 98125, Messina, Italy aut Barresi Gaetano Department of Human Pathology, University of Messina, Azienda Ospedaliera Universitaria "Policlinico G.Martino”, Via Consolare Valeria, 98125, Messina, Italy aut BioMetals Springer Netherlands 24/5(2011-10-01), 775-784 0966-0844 24:5<775 2011 24 10534 https://doi.org/10.1007/s10534-011-9450-5 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10534-011-9450-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tuccari Giovanni Department of Human Pathology, University of Messina, Azienda Ospedaliera Universitaria "Policlinico G.Martino”, Via Consolare Valeria, 98125, Messina, Italy aut NATIONALLICENCE 700 1- Barresi Gaetano Department of Human Pathology, University of Messina, Azienda Ospedaliera Universitaria "Policlinico G.Martino”, Via Consolare Valeria, 98125, Messina, Italy aut NATIONALLICENCE 773 0- BioMetals Springer Netherlands 24/5(2011-10-01), 775-784 0966-0844 24:5<775 2011 24 10534 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer