caa a22 4500 445321970 CHVBK 20180317142707.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10534-011-9443-4 doi (NATIONALLICENCE)springer-10.1007/s10534-011-9443-4 Effects of aluminum exposure on the allergic responses and humoral immune function in rats [Elektronische Daten] [Yanzhu Zhu, Jinfeng Xu, Hao Sun, Chongwei Hu, Hansong Zhao, Bing Shao, Alphajoh Bah, Yanfei Li] This study was conducted to assess effects of aluminum (Al) exposure on allergic responsive reactions and humoral immune function in rats. Forty male Wistar rats (5weeks old) weighed 110-120g were randomly allocated into four groups and were orally exposed to 0, 64.18, 128.36, and 256.72mg/kg body weight aluminum trichloride in drinking water for 120days. The levels of immunoglobulin (Ig) G, IgA, IgM, IgE, Complement factor (C)3, and C4 in serum were determined by ELISA and nephelometric assays at the end of experiment. The results showed that the levels of IgM, C3, and C4 were lowered, and the levels of IgG, IgA, and IgE were increased in an Al-dose dependent manner. The increased in IgE level and the decreased in C3 and C4 levels indicate that Al induces allergic responses in rats; while the increased levels in IgG and IgA and the decreased level in IgM suggest that Al disorders the humoral immune function in rats. Springer Science+Business Media, LLC., 2011 Aluminum exposure nationallicence Allergic responses nationallicence Humoral immune function nationallicence Rats nationallicence Zhu Yanzhu College of Veterinary Medicine, Northeast Agricultural University, 150030, Harbin, China aut Xu Jinfeng College of Animal Sciences and Technology, Heilongjiang Bayi Agricultural University, 163319, Daqing, China aut Sun Hao College of Veterinary Medicine, Northeast Agricultural University, 150030, Harbin, China aut Hu Chongwei College of Veterinary Medicine, Northeast Agricultural University, 150030, Harbin, China aut Zhao Hansong College of Veterinary Medicine, Northeast Agricultural University, 150030, Harbin, China aut Shao Bing College of Veterinary Medicine, Northeast Agricultural University, 150030, Harbin, China aut Bah Alphajoh College of Veterinary Medicine, Northeast Agricultural University, 150030, Harbin, China aut Li Yanfei College of Veterinary Medicine, Northeast Agricultural University, 150030, Harbin, China aut BioMetals Springer Netherlands 24/5(2011-10-01), 973-977 0966-0844 24:5<973 2011 24 10534 https://doi.org/10.1007/s10534-011-9443-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10534-011-9443-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhu Yanzhu College of Veterinary Medicine, Northeast Agricultural University, 150030, Harbin, China aut NATIONALLICENCE 700 1- Xu Jinfeng College of Animal Sciences and Technology, Heilongjiang Bayi Agricultural University, 163319, Daqing, China aut NATIONALLICENCE 700 1- Sun Hao College of Veterinary Medicine, Northeast Agricultural University, 150030, Harbin, China aut NATIONALLICENCE 700 1- Hu Chongwei College of Veterinary Medicine, Northeast Agricultural University, 150030, Harbin, China aut NATIONALLICENCE 700 1- Zhao Hansong College of Veterinary Medicine, Northeast Agricultural University, 150030, Harbin, China aut NATIONALLICENCE 700 1- Shao Bing College of Veterinary Medicine, Northeast Agricultural University, 150030, Harbin, China aut NATIONALLICENCE 700 1- Bah Alphajoh College of Veterinary Medicine, Northeast Agricultural University, 150030, Harbin, China aut NATIONALLICENCE 700 1- Li Yanfei College of Veterinary Medicine, Northeast Agricultural University, 150030, Harbin, China aut NATIONALLICENCE 773 0- BioMetals Springer Netherlands 24/5(2011-10-01), 973-977 0966-0844 24:5<973 2011 24 10534 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer