caa a22 4500 445322063 CHVBK 20180317142707.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10534-010-9402-5 doi (NATIONALLICENCE)springer-10.1007/s10534-010-9402-5 Protective effects of Syzygium cumini seed extract against methylmercury-induced sistemic toxicity in neonatal rats [Elektronische Daten] [F. Abdalla, L. Bellé, P. Bitencourt, K. De Bona, R. Zanette, A. Boligon, M. Athayde, A. Pigatto, M. Moretto] Syzygium cumini (L.) Skeels (Sc) belongs to the medicinal plants with an important source of phenolic compounds. Sc has been shown to possess antioxidant and anti-inflammatory properties. Methylmercury (MeHg), a highly toxic environmental pollutant, induces oxidative stress and dysfunction in many cell types. This study was aimed to evaluate the effect of aqueous seed extract of Sc (ASc) on MeHg-induced toxicity in rats. Two-day-old rats (P2) received a single dose of MeHg (10mg/kg) and two doses of ASc (0.9mg/kg) per os. After two days, the effects of the treatment were investigated in the cerebral cortex, hippocampus, kidney, liver and urine samples. Our results demonstrated that N-acetyl-β-d-glucosaminidase (NAG) activity in the kidney and urine, the lipid peroxidation levels in the liver and kidney samples, as well as the adenosine deaminase (ADA) activity in the hippocampus, kidney and liver were higher in MeHg-group when compared to the control group. The administration of ASc reverted the toxic effects of MeHg. It is noteworthy to observe that the main compounds present in the ASc, as gallic acid (the major component), chlorogenic acid and rutin, might be the responsible for such benefit, since they were found to display antioxidant properties. Springer Science+Business Media, LLC., 2011 Methylmercury nationallicence Syzygium cumini nationallicence N -acetyl-β- d -glucosaminidase nationallicence Rat nationallicence Adenosine deaminase nationallicence Abdalla F. Postgraduate Program in Pharmaceutical Sciences, Health Science Center, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil aut Bellé L. Postgraduate Program in Pharmacology, Health Science Center, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil aut Bitencourt P. Postgraduate Program in Pharmaceutical Sciences, Health Science Center, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil aut De Bona K. Postgraduate Program in Pharmaceutical Sciences, Health Science Center, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil aut Zanette R. Postgraduate Program in Pharmacology, Health Science Center, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil aut Boligon A. Postgraduate Program in Pharmaceutical Sciences, Health Science Center, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil aut Athayde M. Postgraduate Program in Pharmaceutical Sciences, Health Science Center, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil aut Pigatto A. Franciscan University Center--UNIFRA, Santa Maria, RS, Brazil aut Moretto M. Postgraduate Program in Pharmaceutical Sciences, Health Science Center, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil aut BioMetals Springer Netherlands 24/2(2011-04-01), 349-356 0966-0844 24:2<349 2011 24 10534 https://doi.org/10.1007/s10534-010-9402-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10534-010-9402-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Abdalla F. Postgraduate Program in Pharmaceutical Sciences, Health Science Center, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil aut NATIONALLICENCE 700 1- Bellé L. Postgraduate Program in Pharmacology, Health Science Center, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil aut NATIONALLICENCE 700 1- Bitencourt P. Postgraduate Program in Pharmaceutical Sciences, Health Science Center, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil aut NATIONALLICENCE 700 1- De Bona K. Postgraduate Program in Pharmaceutical Sciences, Health Science Center, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil aut NATIONALLICENCE 700 1- Zanette R. Postgraduate Program in Pharmacology, Health Science Center, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil aut NATIONALLICENCE 700 1- Boligon A. Postgraduate Program in Pharmaceutical Sciences, Health Science Center, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil aut NATIONALLICENCE 700 1- Athayde M. Postgraduate Program in Pharmaceutical Sciences, Health Science Center, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil aut NATIONALLICENCE 700 1- Pigatto A. Franciscan University Center--UNIFRA, Santa Maria, RS, Brazil aut NATIONALLICENCE 700 1- Moretto M. Postgraduate Program in Pharmaceutical Sciences, Health Science Center, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil aut NATIONALLICENCE 773 0- BioMetals Springer Netherlands 24/2(2011-04-01), 349-356 0966-0844 24:2<349 2011 24 10534 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer