caa a22 4500 44532211X CHVBK 20180317142707.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10534-010-9387-0 doi (NATIONALLICENCE)springer-10.1007/s10534-010-9387-0 A significant relationship between mercury exposure from dental amalgams and urinary porphyrins: a further assessment of the Casa Pia children's dental amalgam trial [Elektronische Daten] [David Geier, Thomas Carmody, Janet Kern, Paul King, Mark Geier] Previous studies noted specific changes in urinary porphyrin excretion patterns associated with exposure to mercury (Hg) in animals and humans. In our study, urinary porphyrin concentrations were examined in normal children 8-18years-old from a reanalysis of data provided from a randomized, prospective clinical trial that was designed to evaluate the potential health consequences of prolonged exposure to Hg from dental amalgam fillings (the parent study). Our analysis examined dose-dependent correlations between increasing Hg exposure from dental amalgams and urinary porphyrins utilizing statistical models with adjustments for the baseline level (i.e. study year 1) of the following variables: urinary Hg, each urinary porphyrin measure, gender, race, and the level of lead (Pb) in each subject's blood. Significant dose-dependent correlations between cumulative exposure to Hg from dental amalgams and urinary porphyrins associated with Hg body-burden (pentacarboxyporphyrin, precoproporphyrin, and coproporphyrin) were observed. Overall, 5-10% increases in Hg-associated porphyrins for subjects receiving an average number of dental amalgam fillings in comparison to subjects receiving only composite fillings were observed over the 8-year course of the study. In contrast, no significant correlations were observed between cumulative exposure to Hg from dental amalgams and urinary porphyrins not associated with Hg body-burden (uroporphyrin, heptacarboxyporphyrin, and hexacarboxyporphyrin). In conclusion, our study, in contrast to the no-effect results published from the parent study, further establishes the sensitivity and specificity of specific urinary porphyrins as a biomarker for low-level Hg body-burden, and also reveals that dental amalgams are a significant chronic contributor to Hg body-burden. Springer Science+Business Media, LLC., 2010 Body burden nationallicence Dental amalgam nationallicence Mercury nationallicence Porphyrin nationallicence Geier David Institute of Chronic Illnesses, Inc., Silver Spring, MD, USA aut Carmody Thomas Institute of Chronic Illnesses, Inc., Silver Spring, MD, USA aut Kern Janet Genetic Consultants of Dallas, Allen, TX, USA aut King Paul CoMeD, Inc., Silver Spring, MD, USA aut Geier Mark ASD Centers, LLC, 14 Redgate Ct, 20905, Silver Spring, MD, USA aut BioMetals Springer Netherlands 24/2(2011-04-01), 215-224 0966-0844 24:2<215 2011 24 10534 https://doi.org/10.1007/s10534-010-9387-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10534-010-9387-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Geier David Institute of Chronic Illnesses, Inc., Silver Spring, MD, USA aut NATIONALLICENCE 700 1- Carmody Thomas Institute of Chronic Illnesses, Inc., Silver Spring, MD, USA aut NATIONALLICENCE 700 1- Kern Janet Genetic Consultants of Dallas, Allen, TX, USA aut NATIONALLICENCE 700 1- King Paul CoMeD, Inc., Silver Spring, MD, USA aut NATIONALLICENCE 700 1- Geier Mark ASD Centers, LLC, 14 Redgate Ct, 20905, Silver Spring, MD, USA aut NATIONALLICENCE 773 0- BioMetals Springer Netherlands 24/2(2011-04-01), 215-224 0966-0844 24:2<215 2011 24 10534 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer