caa a22 4500 445322977 CHVBK 20180317142710.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s10681-010-0311-z doi (NATIONALLICENCE)springer-10.1007/s10681-010-0311-z Durable resistance to the wheat rusts: integrating systems biology and traditional phenotype-based research methods to guide the deployment of resistance genes [Elektronische Daten] [Iago Lowe, Dario Cantu, Jorge Dubcovsky] Genes which confer partial resistance to the rusts in wheat figure prominently in discussions of potential durable resistance strategies. The positional cloning of the first of these genes, Lr34/Yr18 and Yr36, has revealed different protein structures, suggesting that the category of partial resistance genes, as defined by phenotype, likely groups together suites of functionally heterogenous genes. With the number of mapped partial rust resistance genes increasing rapidly as a result of ongoing advances in marker and sequencing technologies, breeding programs needing to select and prioritize genes for deployment confront a fundamental question: which genes or gene combinations are more likely to provide durable protection against these evolving pathogens? We argue that a refined classification of partial rust resistance genes is required to start answering this question, one based not merely on disease phenotype but also on gene cloning, molecular functional characterization, and interactions with other host and pathogen proteins. Combined with accurate and detailed disease phenotyping and standard genetic studies, an integrated wheat-rust interactome promises to provide the basis for a functional classification of partial resistance genes and thus a conceptual framework for their rational deployment. The Author(s), 2010 Puccinia nationallicence Triticum aestivum nationallicence Partial resistance nationallicence Interactome nationallicence Breeding nationallicence Lowe Iago Department of Plant Sciences, University of California - Davis, One Shields Ave, 95616, Davis, CA, USA aut Cantu Dario Department of Plant Sciences, University of California - Davis, One Shields Ave, 95616, Davis, CA, USA aut Dubcovsky Jorge Department of Plant Sciences, University of California - Davis, One Shields Ave, 95616, Davis, CA, USA aut Euphytica Springer Netherlands 179/1(2011-05-01), 69-79 0014-2336 179:1<69 2011 179 10681 https://doi.org/10.1007/s10681-010-0311-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10681-010-0311-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lowe Iago Department of Plant Sciences, University of California - Davis, One Shields Ave, 95616, Davis, CA, USA aut NATIONALLICENCE 700 1- Cantu Dario Department of Plant Sciences, University of California - Davis, One Shields Ave, 95616, Davis, CA, USA aut NATIONALLICENCE 700 1- Dubcovsky Jorge Department of Plant Sciences, University of California - Davis, One Shields Ave, 95616, Davis, CA, USA aut NATIONALLICENCE 773 0- Euphytica Springer Netherlands 179/1(2011-05-01), 69-79 0014-2336 179:1<69 2011 179 10681 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer