caa a22 4500 44532628X CHVBK 20180317142721.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10989-010-9237-5 doi (NATIONALLICENCE)springer-10.1007/s10989-010-9237-5 Predicting Therapeutic Template by Evaluating the Structural Stability of Anti-Cancer Peptides—A Computational Approach [Elektronische Daten] [K. Ramanathan, V. Shanthi, R. Rajasekaran, C. Sudandiradoss, C. Doss, Rao Sethumadhavan] Clinically significant antibiotic resistance has evolved against virtually every antibiotic deployed. Yet the development of new classes of antibiotics has lagged far behind our growing need for such drugs. Antimicrobial peptides (AMPs) have emerged as novel therapeutics hailed for their bactericidal and immunomodulatory properties. However, the process of optimizing antimicrobial peptide stability, using large peptide libraries is both tedious and expensive. The intent of this study is to analyze computationally the stability of anti-cancer peptides (ACPs) and to discover a potential template from a pool of ACPs for therapeutic use. Consequently we highlighted that ACP, NK-Lysin appears advantageous over the other ACPs with respect to stability, and may provide a convenient platform for the development of anticancer therapeutic peptide. Springer Science+Business Media, LLC, 2011 Anti-cancer peptides nationallicence Stabilization centers nationallicence Total energy nationallicence Intra-molecular interactions nationallicence Instability index nationallicence Ramanathan K. School of Bio Sciences and Technology, Vellore Institute of Technology, 632014, Vellore, Tamil Nadu, India aut Shanthi V. School of Bio Sciences and Technology, Vellore Institute of Technology, 632014, Vellore, Tamil Nadu, India aut Rajasekaran R. School of Bio Sciences and Technology, Vellore Institute of Technology, 632014, Vellore, Tamil Nadu, India aut Sudandiradoss C. School of Bio Sciences and Technology, Vellore Institute of Technology, 632014, Vellore, Tamil Nadu, India aut Doss C. School of Bio Sciences and Technology, Vellore Institute of Technology, 632014, Vellore, Tamil Nadu, India aut Sethumadhavan Rao School of Bio Sciences and Technology, Vellore Institute of Technology, 632014, Vellore, Tamil Nadu, India aut International Journal of Peptide Research and Therapeutics Springer Netherlands 17/1(2011-03-01), 31-38 1573-3149 17:1<31 2011 17 10989 https://doi.org/10.1007/s10989-010-9237-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10989-010-9237-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ramanathan K. School of Bio Sciences and Technology, Vellore Institute of Technology, 632014, Vellore, Tamil Nadu, India aut NATIONALLICENCE 700 1- Shanthi V. School of Bio Sciences and Technology, Vellore Institute of Technology, 632014, Vellore, Tamil Nadu, India aut NATIONALLICENCE 700 1- Rajasekaran R. School of Bio Sciences and Technology, Vellore Institute of Technology, 632014, Vellore, Tamil Nadu, India aut NATIONALLICENCE 700 1- Sudandiradoss C. School of Bio Sciences and Technology, Vellore Institute of Technology, 632014, Vellore, Tamil Nadu, India aut NATIONALLICENCE 700 1- Doss C. School of Bio Sciences and Technology, Vellore Institute of Technology, 632014, Vellore, Tamil Nadu, India aut NATIONALLICENCE 700 1- Sethumadhavan Rao School of Bio Sciences and Technology, Vellore Institute of Technology, 632014, Vellore, Tamil Nadu, India aut NATIONALLICENCE 773 0- International Journal of Peptide Research and Therapeutics Springer Netherlands 17/1(2011-03-01), 31-38 1573-3149 17:1<31 2011 17 10989 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer