caa a22 4500 445326344 CHVBK 20180317142722.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10989-011-9244-1 doi (NATIONALLICENCE)springer-10.1007/s10989-011-9244-1 Quantitative Structure-Activity Relationship Model for Prediction of Protein-Peptide Interaction Binding Affinities between Human Amphiphysin-1 SH3 Domains and Their Peptide Ligands [Elektronische Daten] [Yuan Ding, Yong Lin, Mao Shu, Yuanqiang Wang, Li Wang, Xiaoming Cheng, Zhihua Lin] Protein-protein interaction plays a critical role in signal transduction and many other key biological processes. The present study evaluated four parameters selected from among 554 physiochemical variables of 20 natural amino acids listed in AAindex, namely, hydrophobicity, electronic properties, steric properties, and hydrogen-bond properties. Human amphiphysin-1 Src homology 3 (SH3) domain-binding decapeptides were the object of analysis. A quantitative structure-activity relationship model of the SH3 domain-binding peptides was constructed using multivariate linear regression. The results showed that the four parameters ably characterize the structure of SH3 domain-binding decapeptides, have definitive physicochemical properties and a low level of computational complexity, are accessible, and may be used in integrated prediction models for other protein-peptide interactions. Springer Science+Business Media, LLC, 2011 SH3 domains nationallicence Peptide ligand nationallicence Quantitative structure-activity relationship, QSAR nationallicence Multivariate linear regression analysis, MLR nationallicence Ding Yuan School of Pharmacy and Bioengineering, Chongqing University of Technology, 400050, Chongqing, People's Republic of China aut Lin Yong School of Pharmacy and Bioengineering, Chongqing University of Technology, 400050, Chongqing, People's Republic of China aut Shu Mao School of Pharmacy and Bioengineering, Chongqing University of Technology, 400050, Chongqing, People's Republic of China aut Wang Yuanqiang School of Pharmacy and Bioengineering, Chongqing University of Technology, 400050, Chongqing, People's Republic of China aut Wang Li Institute of Immunology of PLA, Third Military Medical University, 400038, Chongqing, People's Republic of China aut Cheng Xiaoming Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University, 400037, Chongqing, People's Republic of China aut Lin Zhihua School of Pharmacy and Bioengineering, Chongqing University of Technology, 400050, Chongqing, People's Republic of China aut International Journal of Peptide Research and Therapeutics Springer Netherlands 17/1(2011-03-01), 75-79 1573-3149 17:1<75 2011 17 10989 https://doi.org/10.1007/s10989-011-9244-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10989-011-9244-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ding Yuan School of Pharmacy and Bioengineering, Chongqing University of Technology, 400050, Chongqing, People's Republic of China aut NATIONALLICENCE 700 1- Lin Yong School of Pharmacy and Bioengineering, Chongqing University of Technology, 400050, Chongqing, People's Republic of China aut NATIONALLICENCE 700 1- Shu Mao School of Pharmacy and Bioengineering, Chongqing University of Technology, 400050, Chongqing, People's Republic of China aut NATIONALLICENCE 700 1- Wang Yuanqiang School of Pharmacy and Bioengineering, Chongqing University of Technology, 400050, Chongqing, People's Republic of China aut NATIONALLICENCE 700 1- Wang Li Institute of Immunology of PLA, Third Military Medical University, 400038, Chongqing, People's Republic of China aut NATIONALLICENCE 700 1- Cheng Xiaoming Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University, 400037, Chongqing, People's Republic of China aut NATIONALLICENCE 700 1- Lin Zhihua School of Pharmacy and Bioengineering, Chongqing University of Technology, 400050, Chongqing, People's Republic of China aut NATIONALLICENCE 773 0- International Journal of Peptide Research and Therapeutics Springer Netherlands 17/1(2011-03-01), 75-79 1573-3149 17:1<75 2011 17 10989 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer