caa a22 4500 445326433 CHVBK 20180317142722.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s10989-011-9253-0 doi (NATIONALLICENCE)springer-10.1007/s10989-011-9253-0 Two Novel Anticancer Peptides from Aurein1.2 [Elektronische Daten] [Shahrbanoo Karbalaeemohammad, Hossein Naderi-Manesh] Aurein1.2 is a cationic peptide with antimicrobial and anticancer activity. In order to find a novel peptide with this activity, aurein1.2 was utilized as a template and the sequences were designed by a RosettaDesign server with our proposed pattern. As a result, tempY was designed and synthesized, and its structural and biological activity was investigated. TempY has a sequence similar to that of the temporins group but with potent antibacterial properties against Gram-positive bacteria and effective anticancer activity (LC50 is 20-30μg/ml). This latter activity may be due to the tyrosine at the C terminus of the peptide. Kar peptide is another model derived from the complete design of aurein1.2. Kar is only active against A549 cells. The net charge of Kar is four, and it is inactive against Gram-positive bacteria and MCF-7 cells, which may be due to the high positive-charge density on the surface of peptide. Springer Science+Business Media, LLC, 2011 Anticancer activity nationallicence Peptide nationallicence Temporin nationallicence Aurein1.2 nationallicence Antimicrobial activity nationallicence Karbalaeemohammad Shahrbanoo Department of Biophysics & Biochemistry, Tarbiat Modares University, Tehran, Iran aut Naderi-Manesh Hossein Department of Biophysics & Biochemistry, Tarbiat Modares University, Tehran, Iran aut International Journal of Peptide Research and Therapeutics Springer Netherlands 17/3(2011-09-01), 159-164 1573-3149 17:3<159 2011 17 10989 https://doi.org/10.1007/s10989-011-9253-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10989-011-9253-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Karbalaeemohammad Shahrbanoo Department of Biophysics & Biochemistry, Tarbiat Modares University, Tehran, Iran aut NATIONALLICENCE 700 1- Naderi-Manesh Hossein Department of Biophysics & Biochemistry, Tarbiat Modares University, Tehran, Iran aut NATIONALLICENCE 773 0- International Journal of Peptide Research and Therapeutics Springer Netherlands 17/3(2011-09-01), 159-164 1573-3149 17:3<159 2011 17 10989 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer