caa a22 4500 44532645X CHVBK 20180317142722.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s10989-011-9257-9 doi (NATIONALLICENCE)springer-10.1007/s10989-011-9257-9 Secretogranin II and its Derivative Peptide, Manserin, are Differentially Localized in Purkinje Cells and Unipolar Brush Cells in the Rat Cerebellum [Elektronische Daten] [Takeshi Ohkawara, Akiko Oyabu, Michiru Ida-Eto, Yasura Tashiro, Kaori Tano, Fumio Nasu, Naoko Narita, Masaaki Narita] The cerebellum has long been recognized as the primary center of motor coordination in the central nervous system. Cerebellar neuropeptides have been postulated to be involved in such motor coordination, though this role is not fully understood. We herein investigated the localization of novel neuropeptide, "manserin” in the adult rat cerebellum. Punctate signals of manserin immunoreactivity were observed in the granular layer of the rat cerebellum. Manserin signals were also observed in the fibers and fiber terminals in the granular layer as well as the molecular layer. Manserin did not localize in Purkinje cells. Interestingly, cerebellar manserin was preferentially colocalized with unipolar brush cells, a class of excitatory granular layer interneuron, which are known to be involved in vestibullocerebellar functions. These results indicate that manserin plays pivotal roles in the cerebellar functions. Springer Science+Business Media, LLC, 2011 Cerebellum nationallicence Chromogranin nationallicence Manserin nationallicence Neuropeptide nationallicence Secretogranin nationallicence Unipolar brush cell nationallicence Ohkawara Takeshi Department of Developmental and Regenerative Medicine, Mie University, Graduate School of Medicine, 2-174, Edobashi, Tsu, 514-8507, Mie, Japan aut Oyabu Akiko Department of Developmental and Regenerative Medicine, Mie University, Graduate School of Medicine, 2-174, Edobashi, Tsu, 514-8507, Mie, Japan aut Ida-Eto Michiru Department of Developmental and Regenerative Medicine, Mie University, Graduate School of Medicine, 2-174, Edobashi, Tsu, 514-8507, Mie, Japan aut Tashiro Yasura Department of Developmental and Regenerative Medicine, Mie University, Graduate School of Medicine, 2-174, Edobashi, Tsu, 514-8507, Mie, Japan aut Tano Kaori Department of Acupuncture and Moxibustion, Suzuka University of Medical Science, Mie, Japan aut Nasu Fumio Department of Acupuncture and Moxibustion, Suzuka University of Medical Science, Mie, Japan aut Narita Naoko Department of Education, Bunkyo University, Saitama, Japan aut Narita Masaaki Department of Developmental and Regenerative Medicine, Mie University, Graduate School of Medicine, 2-174, Edobashi, Tsu, 514-8507, Mie, Japan aut International Journal of Peptide Research and Therapeutics Springer Netherlands 17/3(2011-09-01), 193-199 1573-3149 17:3<193 2011 17 10989 https://doi.org/10.1007/s10989-011-9257-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10989-011-9257-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ohkawara Takeshi Department of Developmental and Regenerative Medicine, Mie University, Graduate School of Medicine, 2-174, Edobashi, Tsu, 514-8507, Mie, Japan aut NATIONALLICENCE 700 1- Oyabu Akiko Department of Developmental and Regenerative Medicine, Mie University, Graduate School of Medicine, 2-174, Edobashi, Tsu, 514-8507, Mie, Japan aut NATIONALLICENCE 700 1- Ida-Eto Michiru Department of Developmental and Regenerative Medicine, Mie University, Graduate School of Medicine, 2-174, Edobashi, Tsu, 514-8507, Mie, Japan aut NATIONALLICENCE 700 1- Tashiro Yasura Department of Developmental and Regenerative Medicine, Mie University, Graduate School of Medicine, 2-174, Edobashi, Tsu, 514-8507, Mie, Japan aut NATIONALLICENCE 700 1- Tano Kaori Department of Acupuncture and Moxibustion, Suzuka University of Medical Science, Mie, Japan aut NATIONALLICENCE 700 1- Nasu Fumio Department of Acupuncture and Moxibustion, Suzuka University of Medical Science, Mie, Japan aut NATIONALLICENCE 700 1- Narita Naoko Department of Education, Bunkyo University, Saitama, Japan aut NATIONALLICENCE 700 1- Narita Masaaki Department of Developmental and Regenerative Medicine, Mie University, Graduate School of Medicine, 2-174, Edobashi, Tsu, 514-8507, Mie, Japan aut NATIONALLICENCE 773 0- International Journal of Peptide Research and Therapeutics Springer Netherlands 17/3(2011-09-01), 193-199 1573-3149 17:3<193 2011 17 10989 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer