caa a22 4500 445326484 CHVBK 20180317142722.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s10989-011-9258-8 doi (NATIONALLICENCE)springer-10.1007/s10989-011-9258-8 QSAR Study on Insect Neuropeptide Potencies Based on a Novel Set of Parameters of Amino Acids by Using OSC-PLS Method [Elektronische Daten] [Yong Lin, Haixia Long, Juan Wang, Mao Shu, Yuanqiang Wang, Li Wang, Zhihua Lin] The potencies of natural adipokinetic hormones and synthetic variants (short peptides) have been obtained in Locusta migratoria. This short peptides (a total of sixty-nine analogues) data was used to construct the mathematical models of the hormone potencies. The sequence variations of amino acids in both natural and artificial adipokinetic hormone analogues were characterized by using a set of descriptors proposed in our laboratory, then QSAR models were developed successfully by using orthogonal signal correction combines with partial least squares (OSC-PLS) method. The cross validation correlation coefficients (Q 2) were up to 0.942. The results show that the descriptors proposed in this study will be useful in structure characterization and activity prediction of biological molecules. Springer Science+Business Media, LLC, 2011 Adipokinetic hormone nationallicence Quantitative structure-activity relationship (QSAR) nationallicence Orthogonal signal correction (OSC) nationallicence Partial least squares (PLS) nationallicence Lin Yong College of Chemical and Bioengineering, Chongqing University of Technology, 400054, Chongqing, People's Republic of China aut Long Haixia Cancer Center of People's Liberation Army (PLA), Xinqiao Hospital, Third Military Medical University, 400037, Chongqing, People's Republic of China aut Wang Juan School of Pharmacy and Bioengineering, Chongqing University of Technology, 400054, Chongqing, People's Republic of China aut Shu Mao School of Pharmacy and Bioengineering, Chongqing University of Technology, 400054, Chongqing, People's Republic of China aut Wang Yuanqiang School of Pharmacy and Bioengineering, Chongqing University of Technology, 400054, Chongqing, People's Republic of China aut Wang Li Institute of Immunology of PLA, Third Military Medical University, 400038, Chongqing, People's Republic of China aut Lin Zhihua School of Pharmacy and Bioengineering, Chongqing University of Technology, 400054, Chongqing, People's Republic of China aut International Journal of Peptide Research and Therapeutics Springer Netherlands 17/3(2011-09-01), 201-208 1573-3149 17:3<201 2011 17 10989 https://doi.org/10.1007/s10989-011-9258-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10989-011-9258-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lin Yong College of Chemical and Bioengineering, Chongqing University of Technology, 400054, Chongqing, People's Republic of China aut NATIONALLICENCE 700 1- Long Haixia Cancer Center of People's Liberation Army (PLA), Xinqiao Hospital, Third Military Medical University, 400037, Chongqing, People's Republic of China aut NATIONALLICENCE 700 1- Wang Juan School of Pharmacy and Bioengineering, Chongqing University of Technology, 400054, Chongqing, People's Republic of China aut NATIONALLICENCE 700 1- Shu Mao School of Pharmacy and Bioengineering, Chongqing University of Technology, 400054, Chongqing, People's Republic of China aut NATIONALLICENCE 700 1- Wang Yuanqiang School of Pharmacy and Bioengineering, Chongqing University of Technology, 400054, Chongqing, People's Republic of China aut NATIONALLICENCE 700 1- Wang Li Institute of Immunology of PLA, Third Military Medical University, 400038, Chongqing, People's Republic of China aut NATIONALLICENCE 700 1- Lin Zhihua School of Pharmacy and Bioengineering, Chongqing University of Technology, 400054, Chongqing, People's Republic of China aut NATIONALLICENCE 773 0- International Journal of Peptide Research and Therapeutics Springer Netherlands 17/3(2011-09-01), 201-208 1573-3149 17:3<201 2011 17 10989 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer