caa a22 4500 445326492 CHVBK 20180317142722.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s10989-011-9263-y doi (NATIONALLICENCE)springer-10.1007/s10989-011-9263-y Ghrelin Acts as an Antioxidant Agent in the Rat Kidney [Elektronische Daten] [Shima Neamati, Masoud Alirezaei, Arash Kheradmand] Ghrelin has recently been shown to improve renal function in rat with acute renal failure. In this setting, the protective effects have been suggested to be due to its antioxidant properties. Thus, the aim of this study was to measure the antioxidant abilities of this hormone via enzymatic and lipid peroxidation analyses. Wistar rats were divided into two control and two treatment groups, the treated animals receiving 3nmol of ghrelin as subcutaneous administrations on each of 10 consecutive days and physiological saline injected to controls. Catalase (CAT) activity was significantly higher in the treated animals when compared to controls, while in contrast, lipid peroxidation measured by thiobarbituric acid reactive substances (TBARS), was significantly reduced in the ghrelin treated animals. Furthermore, superoxide dismutase (SOD) activity and glutathione (GSH) content were both much higher in treated female rats than in controls and although there was a slight increase in glutathione peroxidase (GPx) activity in kidneys of ghrelin treated rats, the difference was insignificant. These findings suggest that ghrelin has beneficial antioxidant properties in the rat kidney by increasing antioxidant enzyme activities. These effects were more noticeable in treated female rats, possibly due to higher levels of estrogen. Springer Science+Business Media, LLC, 2011 Ghrelin nationallicence Antioxidant enzymes nationallicence TBARS nationallicence Kidney nationallicence Rat nationallicence Neamati Shima Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorram Abad, Iran aut Alirezaei Masoud Division of Biochemistry, School of Veterinary Medicine, Lorestan University, P.O. Box 465, Khorram Abad, Iran aut Kheradmand Arash Department of Clinical Sciences, School of Veterinary Medicine, Lorestan University, P.O. Box 465, Khorram Abad, Iran aut International Journal of Peptide Research and Therapeutics Springer Netherlands 17/3(2011-09-01), 239-245 1573-3149 17:3<239 2011 17 10989 https://doi.org/10.1007/s10989-011-9263-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10989-011-9263-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Neamati Shima Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorram Abad, Iran aut NATIONALLICENCE 700 1- Alirezaei Masoud Division of Biochemistry, School of Veterinary Medicine, Lorestan University, P.O. Box 465, Khorram Abad, Iran aut NATIONALLICENCE 700 1- Kheradmand Arash Department of Clinical Sciences, School of Veterinary Medicine, Lorestan University, P.O. Box 465, Khorram Abad, Iran aut NATIONALLICENCE 773 0- International Journal of Peptide Research and Therapeutics Springer Netherlands 17/3(2011-09-01), 239-245 1573-3149 17:3<239 2011 17 10989 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer