caa a22 4500 445326530 CHVBK 20180317142722.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10989-011-9268-6 doi (NATIONALLICENCE)springer-10.1007/s10989-011-9268-6 A Synthetic Peptide Derived from NK-Lysin with Activity Against Mycobacterium tuberculosis and its Structure-Function Relationship [Elektronische Daten] [Gu Hao, Dai Rongji, Qiu Kui, Teng Zhongqiu, Wang Heyao] As appearance of drug resistant and multidrug resistant strains of Mycobacterium tuberculosis, antibiotics were no longer the only way to inhibit M. tuberculosis. It was shown that the porcine peptide NK-lysin is active against various microbes by interacting with microbial membranes. The NK-lysin-derived peptide has been demonstrated to possess stronger effect. Under this motivation, we synthesized a short peptide (N22) derived from an active fragment of NK-lysin—an important antimycobaterial domain involving the loop and the α-helical structure. Furthermore, we studied its stability and biological activity in vitro. The results showed that it inhibited the growth of M. tuberculosis H37Rv and had a low toxicity to human erythrocyte. Springer Science+Business Media, LLC, 2011 NK-lysin nationallicence Mycobacterium tuberculosis nationallicence Antimycobacterial activity nationallicence Active fragments nationallicence Hao Gu School of Life Science, Beijing Institute of Technology, Beijing, China aut Rongji Dai School of Life Science, Beijing Institute of Technology, Beijing, China aut Kui Qiu Department of Pharmacy, Beijing Chao-Yang Hospital, No. 5, Gongti South Road, Chaoyang District, 100020, Beijing, China aut Zhongqiu Teng School of Life Science, Beijing Institute of Technology, Beijing, China aut Heyao Wang Department of Pharmacy, Beijing Chao-Yang Hospital, No. 5, Gongti South Road, Chaoyang District, 100020, Beijing, China aut International Journal of Peptide Research and Therapeutics Springer Netherlands 17/4(2011-12-01), 301-306 1573-3149 17:4<301 2011 17 10989 https://doi.org/10.1007/s10989-011-9268-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10989-011-9268-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hao Gu School of Life Science, Beijing Institute of Technology, Beijing, China aut NATIONALLICENCE 700 1- Rongji Dai School of Life Science, Beijing Institute of Technology, Beijing, China aut NATIONALLICENCE 700 1- Kui Qiu Department of Pharmacy, Beijing Chao-Yang Hospital, No. 5, Gongti South Road, Chaoyang District, 100020, Beijing, China aut NATIONALLICENCE 700 1- Zhongqiu Teng School of Life Science, Beijing Institute of Technology, Beijing, China aut NATIONALLICENCE 700 1- Heyao Wang Department of Pharmacy, Beijing Chao-Yang Hospital, No. 5, Gongti South Road, Chaoyang District, 100020, Beijing, China aut NATIONALLICENCE 773 0- International Journal of Peptide Research and Therapeutics Springer Netherlands 17/4(2011-12-01), 301-306 1573-3149 17:4<301 2011 17 10989 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer