caa a22 4500 445326662 CHVBK 20180317142723.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10989-011-9248-x doi (NATIONALLICENCE)springer-10.1007/s10989-011-9248-x Solid Phase and Solution Phase Synthesis of Gamma Amino Acid Homo-Oligomers and Mixed Oligomers [Elektronische Daten] [K. Bhaskara Reddy, Dokka Mallikarjunasarma, Kamana Bulliraju, Vanjivaka Sreelatha, Y. Bharathi Kumari, Ramesh Dandala, Kuppanna Ananda] An efficient stepwise synthesis of homo-oligomers and mixed oligomers of gabapentin and pregabalin on solid support using Fmoc-protected derivatives and HBTU/HOBt/DIEA as coupling agent is described. The synthesis was also carried out using solution phase methodology. The Gpn/Pgn homo oligomers and mixed oligomers forms C9 helix in solution as determined by NMR study. Chiral as well as achiral gamma amino acids were used for the synthesis of oligomers in order to investigate the secondary structural preferences. Graphical Abstract: Springer Science+Business Media, LLC, 2011 Gamma amino acid oligomers nationallicence Solid phase peptide synthesis nationallicence C9 hydrogen bonds nationallicence Helical structures nationallicence Bhaskara Reddy K. Chemical Research Division, Matrix Laboratories Ltd., Anrich Industrial Estate, Bollaram, 502325, Hyderabad, India aut Mallikarjunasarma Dokka Chemical Research Division, Matrix Laboratories Ltd., Anrich Industrial Estate, Bollaram, 502325, Hyderabad, India aut Bulliraju Kamana Chemical Research Division, Matrix Laboratories Ltd., Anrich Industrial Estate, Bollaram, 502325, Hyderabad, India aut Sreelatha Vanjivaka Chemical Research Division, Matrix Laboratories Ltd., Anrich Industrial Estate, Bollaram, 502325, Hyderabad, India aut Bharathi Kumari Y. Department of Chemistry, College of Engineering, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, 500085, Hyderabad, India aut Dandala Ramesh Chemical Research Division, Matrix Laboratories Ltd., Anrich Industrial Estate, Bollaram, 502325, Hyderabad, India aut Ananda Kuppanna Chemical Research Division, Matrix Laboratories Ltd., Anrich Industrial Estate, Bollaram, 502325, Hyderabad, India aut International Journal of Peptide Research and Therapeutics Springer Netherlands 17/2(2011-06-01), 113-121 1573-3149 17:2<113 2011 17 10989 https://doi.org/10.1007/s10989-011-9248-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10989-011-9248-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bhaskara Reddy K. Chemical Research Division, Matrix Laboratories Ltd., Anrich Industrial Estate, Bollaram, 502325, Hyderabad, India aut NATIONALLICENCE 700 1- Mallikarjunasarma Dokka Chemical Research Division, Matrix Laboratories Ltd., Anrich Industrial Estate, Bollaram, 502325, Hyderabad, India aut NATIONALLICENCE 700 1- Bulliraju Kamana Chemical Research Division, Matrix Laboratories Ltd., Anrich Industrial Estate, Bollaram, 502325, Hyderabad, India aut NATIONALLICENCE 700 1- Sreelatha Vanjivaka Chemical Research Division, Matrix Laboratories Ltd., Anrich Industrial Estate, Bollaram, 502325, Hyderabad, India aut NATIONALLICENCE 700 1- Bharathi Kumari Y. Department of Chemistry, College of Engineering, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, 500085, Hyderabad, India aut NATIONALLICENCE 700 1- Dandala Ramesh Chemical Research Division, Matrix Laboratories Ltd., Anrich Industrial Estate, Bollaram, 502325, Hyderabad, India aut NATIONALLICENCE 700 1- Ananda Kuppanna Chemical Research Division, Matrix Laboratories Ltd., Anrich Industrial Estate, Bollaram, 502325, Hyderabad, India aut NATIONALLICENCE 773 0- International Journal of Peptide Research and Therapeutics Springer Netherlands 17/2(2011-06-01), 113-121 1573-3149 17:2<113 2011 17 10989 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer