caa a22 4500 445327898 CHVBK 20180317142727.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s10953-011-9709-z doi (NATIONALLICENCE)springer-10.1007/s10953-011-9709-z Solubility of Nonsteroidal Anti-inflammatory Drugs (NSAIDs) in Aqueous Solutions of Non-ionic Surfactants [Elektronische Daten] [Irfan Ullah, Musa Baloch, Gulrez Durrani] The solubilities of two nonsteroidal anti-inflammatory (MELOXICAM and CELECOXIB) drugs, were determined in aqueous solutions of nonionic (Tween 20, Tween 80, Brij 30, Brij 35, Triton X 100, Triton X 114) surfactants. These surfactants have different numbers of oxyethylene units and their micelles showed different aggregation numbers. It is shown that these surfactants have different abilities to solubilize NSAIDs drugs. The solubilities of the drugs increased linearly with the increase in concentration of surfactants. The sizes of micelles remained constant with the addition of the drugs, except for Triton type surfactants in which case the size of the micelles decreased. It was observed that the number of oxyethylene units in the surfactants, aggregation number of the micelles and HLB play key roles in solubilizing the drugs. Springer Science+Business Media, LLC, 2011 NSAIDs nationallicence Surfactants nationallicence OE unit nationallicence Aggregation numbers nationallicence Solubilization nationallicence Micelles nationallicence Ullah Irfan Department of Chemistry, Gomal University, 29050, Dera Ismail Khan, Khyber Pakhtoon Khawa, Pakistan aut Baloch Musa Department of Chemistry, Gomal University, 29050, Dera Ismail Khan, Khyber Pakhtoon Khawa, Pakistan aut Durrani Gulrez Department of Chemistry, Gomal University, 29050, Dera Ismail Khan, Khyber Pakhtoon Khawa, Pakistan aut Journal of Solution Chemistry Springer US; http://www.springer-ny.com 40/7(2011-07-01), 1341-1348 0095-9782 40:7<1341 2011 40 10953 https://doi.org/10.1007/s10953-011-9709-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10953-011-9709-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ullah Irfan Department of Chemistry, Gomal University, 29050, Dera Ismail Khan, Khyber Pakhtoon Khawa, Pakistan aut NATIONALLICENCE 700 1- Baloch Musa Department of Chemistry, Gomal University, 29050, Dera Ismail Khan, Khyber Pakhtoon Khawa, Pakistan aut NATIONALLICENCE 700 1- Durrani Gulrez Department of Chemistry, Gomal University, 29050, Dera Ismail Khan, Khyber Pakhtoon Khawa, Pakistan aut NATIONALLICENCE 773 0- Journal of Solution Chemistry Springer US; http://www.springer-ny.com 40/7(2011-07-01), 1341-1348 0095-9782 40:7<1341 2011 40 10953 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer