caa a22 4500 445327936 CHVBK 20180317142727.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10953-011-9769-0 doi (NATIONALLICENCE)springer-10.1007/s10953-011-9769-0 Solution Thermodynamics and Preferential Solvation of Meloxicam in Propylene Glycol + Water Mixtures [Elektronische Daten] [Andrés Holguín, Daniel Delgado, Fleming Martínez, Yizhak Marcus] The equilibrium solubilities of the analgesic drug meloxicam (MEL) in propylene glycol + water mixtures were determined at several temperatures from 293.15 to 313.15 K. The Gibbs energy, enthalpy, and entropy of solution and of mixing were obtained from these solubility data. The solubility was maximal in neat propylene glycol and very low in pure water at all temperatures studied. A nonlinear plot of Δsoln H° versus Δsoln G° gave a negative slope from pure water up to 0.80 mass fraction of propylene glycol and a positive slope above this composition up to neat propylene glycol, at the mean temperature 303.15 K. Accordingly, the driving mechanism for MEL solubility in the water-rich mixtures was the entropy, probably due to water-structure loss around nonpolar moieties of the drug, while for the propylene glycol-rich mixtures it was the enthalpy, probably due to better solvation of the drug. The preferential solvation of MEL by the components of the solvent was estimated by means of the inverse Kirkwood-Buff integral method, showing rather small preferential solvation of MEL by propylene glycol at all compositions. Springer Science+Business Media, LLC, 2011 Meloxicam nationallicence Propylene glycol solubility nationallicence Solution thermodynamics nationallicence Activity coefficients nationallicence Preferential solvation nationallicence Holguín Andrés Physicochemical and Pharmaceutical Research Group, Department of Pharmacy, National University of Colombia, A.A. 14490, Bogotá, D.C., Colombia aut Delgado Daniel Physicochemical and Pharmaceutical Research Group, Department of Pharmacy, National University of Colombia, A.A. 14490, Bogotá, D.C., Colombia aut Martínez Fleming Physicochemical and Pharmaceutical Research Group, Department of Pharmacy, National University of Colombia, A.A. 14490, Bogotá, D.C., Colombia aut Marcus Yizhak Institute of Chemistry, The Hebrew University of Jerusalem, 91904, Jerusalem, Israel aut Journal of Solution Chemistry Springer US; http://www.springer-ny.com 40/12(2011-12-01), 1987-1999 0095-9782 40:12<1987 2011 40 10953 https://doi.org/10.1007/s10953-011-9769-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10953-011-9769-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Holguín Andrés Physicochemical and Pharmaceutical Research Group, Department of Pharmacy, National University of Colombia, A.A. 14490, Bogotá, D.C., Colombia aut NATIONALLICENCE 700 1- Delgado Daniel Physicochemical and Pharmaceutical Research Group, Department of Pharmacy, National University of Colombia, A.A. 14490, Bogotá, D.C., Colombia aut NATIONALLICENCE 700 1- Martínez Fleming Physicochemical and Pharmaceutical Research Group, Department of Pharmacy, National University of Colombia, A.A. 14490, Bogotá, D.C., Colombia aut NATIONALLICENCE 700 1- Marcus Yizhak Institute of Chemistry, The Hebrew University of Jerusalem, 91904, Jerusalem, Israel aut NATIONALLICENCE 773 0- Journal of Solution Chemistry Springer US; http://www.springer-ny.com 40/12(2011-12-01), 1987-1999 0095-9782 40:12<1987 2011 40 10953 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer