caa a22 4500 445328142 CHVBK 20180317142728.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10953-011-9654-x doi (NATIONALLICENCE)springer-10.1007/s10953-011-9654-x Interaction of 1,4-Dihydroxy-9,10-Anthraquinone with Calf Thymus DNA: AComparison with Anthracycline Anticancer Drugs [Elektronische Daten] [Partha Guin, Saurabh Das, Parikshit Mandal] The anthracycline drugs adriamycin and daunorubicin, efficient in the treatment of various human cancers, form strong intercalation complexes with DNA. The therapeutic efficacy and toxicity of such anticancer drugs are governed by biochemical reactions of the core dihydroxy-9,10-anthraquinone unit. The high cost and toxic side effects of anthracycline drugs limit their use in cancer therapy. For a few decades, efforts have been made to find cheap, less toxic yet efficient analogues of anthracyclines. This work on 1,4-dihydroxy-9,10-anthraquinone (QH2), a simple analogue of the anthracyclines, was carried out to compare its biochemical properties with anthracyclines. UV-Vis and fluorescence spectroscopic methods were used to analyze interaction of the compound with calf thymus DNA. The data were used to evaluate the binding constant and site size. Springer Science+Business Media, LLC, 2011 QH2 nationallicence Calf thymus DNA nationallicence UV-Visible spectroscopy nationallicence Fluorescence nationallicence Binding constant nationallicence Binding site size nationallicence QH2 : 1,4-dihydroxy-9,10-anthraquinone nationallicence ctDNA : calf thymus DNA nationallicence Guin Partha Chemical Sciences Division, Saha Institute of Nuclear Physics, 1/AF-Bidhannagar, 700064, Kolkata, India aut Das Saurabh Department of Chemistry, Jadavpur University, Raja S.C. Mullick Road, 700032, Kolkata, India aut Mandal Parikshit Chemical Sciences Division, Saha Institute of Nuclear Physics, 1/AF-Bidhannagar, 700064, Kolkata, India aut Journal of Solution Chemistry Springer US; http://www.springer-ny.com 40/3(2011-03-01), 492-501 0095-9782 40:3<492 2011 40 10953 https://doi.org/10.1007/s10953-011-9654-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10953-011-9654-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Guin Partha Chemical Sciences Division, Saha Institute of Nuclear Physics, 1/AF-Bidhannagar, 700064, Kolkata, India aut NATIONALLICENCE 700 1- Das Saurabh Department of Chemistry, Jadavpur University, Raja S.C. Mullick Road, 700032, Kolkata, India aut NATIONALLICENCE 700 1- Mandal Parikshit Chemical Sciences Division, Saha Institute of Nuclear Physics, 1/AF-Bidhannagar, 700064, Kolkata, India aut NATIONALLICENCE 773 0- Journal of Solution Chemistry Springer US; http://www.springer-ny.com 40/3(2011-03-01), 492-501 0095-9782 40:3<492 2011 40 10953 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer