caa a22 4500 445328215 CHVBK 20180317142728.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10953-011-9753-8 doi (NATIONALLICENCE)springer-10.1007/s10953-011-9753-8 Shoukry Azza Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt aut Complex Formation Reactions of Promethazine Copper(II) and Various Biologically Relevant Ligands. Synthesis, Equilibrium Constants, Spectroscopic Characterization and Biological Activity [Elektronische Daten] [Azza Shoukry] Binary and ternary complexes of copper(II) involving promethazine, N,N-dimethyl-3-(phenothiazin-10-yl)propylamine (Prom) and various biologically relevant ligands containing different functional groups, were investigated. The ligands (L) are dicarboxylic acids, amino acids, amides and DNA constituents. The ternary complexes of amino acids, dicarboxylic acids or amides are formed by simultaneous reactions. The results showed the formation of Cu(Prom)(L) complexes with amino acids and dicarboxylic acids. The effect of chelate ring size of the dicarboxylic acid complexes on their stability constants was examined. Amides form both Cu(Prom)(L) complexes and the corresponding deprotonated species Cu(Prom)(LH−1). The ternary complexes of copper(II) with (Prom) and DNA are formed in a stepwise process, whereby binding of copper(II) to (Prom) is followed by ligation of the DNA components. DNA constituents form both 1:1 and 1:2 complexes with Cu(Prom)2+. The stability of these ternary complexes was quantitatively compared with their corresponding binary complexes in terms of the parameters Δlog10 K. The values of Δlog10 K indicate that the ternary complexes containing aromatic amino acids were significantly more stable than the complexes containing alkyl- and hydroxyalkyl-substituted amino acids. The concentration distribution of various complex species formed in solution was also evaluated as a function of pH. The solid complexes [Cu(Prom)L)] where L=1,1-cyclobutanedicarboxylic acid (CBDCA), oxalic and malonic acid were isolated and characterized by elemental analysis, infrared, TGA, and magnetic susceptibility measurements. Spectroscopic studies of the complexes revealed that the complexes exhibits square planar coordination with copper(II). The isolated solid complexes have been screened for their antimicrobial activities using the disc diffusion method against some selected bacteria and fungi. The activity data show that the metal complexes are found to have antibacterial and antifungal activity. Springer Science+Business Media, LLC, 2011 Copper(II) nationallicence Promethazine nationallicence Amino acids nationallicence Amides nationallicence DNA constituents nationallicence Stability constant nationallicence Spectroscopic characterization nationallicence Biological activity nationallicence Journal of Solution Chemistry Springer US; http://www.springer-ny.com 40/10(2011-10-01), 1796-1818 0095-9782 40:10<1796 2011 40 10953 https://doi.org/10.1007/s10953-011-9753-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10953-011-9753-8 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Shoukry Azza Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt aut NATIONALLICENCE 773 0- Journal of Solution Chemistry Springer US; http://www.springer-ny.com 40/10(2011-10-01), 1796-1818 0095-9782 40:10<1796 2011 40 10953 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer