caa a22 4500 445328355 CHVBK 20180317142729.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10953-011-9674-6 doi (NATIONALLICENCE)springer-10.1007/s10953-011-9674-6 Cyclodextrins-Kaempferol Inclusion Complexes: Spectroscopic and Reactivity Studies [Elektronische Daten] [Carolina Jullian, Victor Brossard, Iván Gonzalez, Muriel Alfaro, Claudio Olea-Azar] The slightly water-soluble flavonoid kaempferol (KAE) and its inclusion complexes with β-cyclodextrin (βCD), hydroxypropyl-β-cyclodextrin (HPβCD) or heptakis-2,6-O-dimethyl-β-cyclodextrin (DMβCD) were investigated. The stoichiometric ratios and association constants describing the extent of the formation of the complexes have been determined. Binding constants, estimated from fluorescence studies at different temperatures, were analyzed so as to gain information about the mechanisms involved in the association processes. The thermodynamic data for the inclusion of KAE in DMβCD and HPβCD indicated that it is mainly enthalpy-driven whereas for βCD it is an entropy-driven process. Complex formation was monitored by two-dimensional ROESY experiments through the detection of intramolecular dipolar interaction. ROESY experiments provided data indicating that the B-ring of kaempferol is immersed in the apolar cavity with the A- and C-ring protruding from the wider rim for the three cyclodextrins studied. The antioxidant studies of KAE and CDs complexes showed an increment in its antioxidant activity. The complexes behave as better antioxidants than kaempferol alone. Springer Science+Business Media, LLC, 2011 Kaempferol nationallicence Cyclodextrins nationallicence Inclusion complex nationallicence 2D-ROESY nationallicence Thermodynamic study nationallicence ORAC-FL nationallicence Jullian Carolina Departamento Química Orgánica y Fisicoquímica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago de Chile, Chile aut Brossard Victor Departamento Química Orgánica y Fisicoquímica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago de Chile, Chile aut Gonzalez Iván Departamento Química Orgánica y Fisicoquímica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago de Chile, Chile aut Alfaro Muriel Departamento Química Orgánica y Fisicoquímica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago de Chile, Chile aut Olea-Azar Claudio Departamento Química Inorgánica y Analítica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago de Chile, Chile aut Journal of Solution Chemistry Springer US; http://www.springer-ny.com 40/4(2011-04-01), 727-739 0095-9782 40:4<727 2011 40 10953 https://doi.org/10.1007/s10953-011-9674-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10953-011-9674-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jullian Carolina Departamento Química Orgánica y Fisicoquímica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago de Chile, Chile aut NATIONALLICENCE 700 1- Brossard Victor Departamento Química Orgánica y Fisicoquímica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago de Chile, Chile aut NATIONALLICENCE 700 1- Gonzalez Iván Departamento Química Orgánica y Fisicoquímica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago de Chile, Chile aut NATIONALLICENCE 700 1- Alfaro Muriel Departamento Química Orgánica y Fisicoquímica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago de Chile, Chile aut NATIONALLICENCE 700 1- Olea-Azar Claudio Departamento Química Inorgánica y Analítica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago de Chile, Chile aut NATIONALLICENCE 773 0- Journal of Solution Chemistry Springer US; http://www.springer-ny.com 40/4(2011-04-01), 727-739 0095-9782 40:4<727 2011 40 10953 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer