caa a22 4500 44532869X CHVBK 20180317142730.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10953-010-9642-6 doi (NATIONALLICENCE)springer-10.1007/s10953-010-9642-6 Zapała Lidia Department of Inorganic and Analytical Chemistry, Faculty of Chemistry, Rzeszów University of Technology, 6 Powstańców Warszawy Ave., 35-959, Rzeszów, Poland aut Potentiometric Studies on the Equilibria of Flufenamic Acid in Aqueous Solutions and in Two-phase Organic Solvent + Water Systems [Elektronische Daten] [Lidia Zapała] In this paper, the flufenamic acid equilibria in aqueous solution and in two-phase organic solvent + aqueous solution are described and presented. The dissociation constants K a1 and K a2 were determined in MDM + water mixtures. The Yashuda-Shedlovsky extrapolation procedure has been used to obtain the values of K a1 andK a2 in aqueous solutions. The distribution ratio D was measured in the toluene + water system over a wide range of pH by the shaking flask method. Based on the results of potentiometric titrations in two-phase organic solvent (benzene, ethylbenzene, toluene, carbon tetrachloride, chloroform, chlorobenzene, and bromobenzene) + aqueous systems, and using models of single and multistep equilibria, the values of distribution constants K D and dimerization constants K dim were calculated. The influences of polarity of the applied solvents and pH of the aqueous phase, on the speciation of the particular forms of flufenamic acid in both phases, were demonstrated. The Author(s), 2011 Flufenamic acid nationallicence Dissociation constant nationallicence Two-phase equilibria nationallicence Distribution constant nationallicence Journal of Solution Chemistry Springer US; http://www.springer-ny.com 40/2(2011-02-01), 198-210 0095-9782 40:2<198 2011 40 10953 https://doi.org/10.1007/s10953-010-9642-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10953-010-9642-6 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Zapała Lidia Department of Inorganic and Analytical Chemistry, Faculty of Chemistry, Rzeszów University of Technology, 6 Powstańców Warszawy Ave., 35-959, Rzeszów, Poland aut NATIONALLICENCE 773 0- Journal of Solution Chemistry Springer US; http://www.springer-ny.com 40/2(2011-02-01), 198-210 0095-9782 40:2<198 2011 40 10953 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer