caa a22 4500 445329017 CHVBK 20180317142731.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s10143-010-0288-z doi (NATIONALLICENCE)springer-10.1007/s10143-010-0288-z Linear accelerator-based stereotactic radiosurgery of intracranial meningiomas: results of the first 5years of clinical practice [Elektronische Daten] [Osama Abdelaziz, Alaa Kandil, Shaaban El-Assaal, Amro Abdelaziz, Yosry Rostom, Yaser Rashed] Meningiomas are mostly benign but some are atypical or malignant. Surgical resection is curative when complete removal of benign meningiomas is contemplated. Incompletely excised and recurrent tumors are frequently treated with fractionated radiation therapy or stereotactic radiosurgery. The purpose of this study is to evaluate the short-term radiological and functional outcomes of a single center using linear accelerator (Linac) stereotactic radiosurgery for the treatment of intracranial meningiomas. Twenty-nine patients (12 males and 17 females) with 30 meningiomas, in different brain locations (skull base and non-skull base meningiomas), were treated with Linac-based stereotactic radiosurgery. The mean tumor volume was 6.3cm3, and the mean tumor marginal and maximum doses were 10.9 and 15Gy, respectively. The median prescribed isodose line was 80%. The patients were followed-up for a minimum of 3years. Regarding radiological outcome, nine (30%) meningiomas demonstrated evident volume reduction, 19 (63.3%) meningiomas remained unchanged, and two (6.7%) meningiomas increased in size after radiosurgery. The local tumor control rates for skull base meningiomas and non-skull base meningiomas after radiosurgery were 90.9% and 100%, respectively. Regarding functional outcomes, 64% of patients presenting with cranial neuropathies showed improvement of their cranial nerve functions and 29% of patients remained unchanged. One patient had temporary trigeminal neuropathy. Although radiosurgery for meningiomas is generally effective and quite safe in achieving high control rates with minimum morbidity over short- and intermediate-term periods of follow-up, tumor progression might occur in a delayed manner after initial apparent control for few years. We recommend continued follow-up for longer periods to better assess the long-term outcomes. Springer-Verlag, 2010 Linear accelerator nationallicence Meningiomas nationallicence Radiosurgery nationallicence Stereotaxy nationallicence Abdelaziz Osama Department of Neurosurgery, Faculty of Medicine, Alexandria University, P.O. 21521, Alexandria, Egypt aut Kandil Alaa Department of Radiation Oncology and Nuclear Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt aut El-Assaal Shaaban Department of Radiation Oncology and Nuclear Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt aut Abdelaziz Amro Department of Radiation Oncology and Nuclear Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt aut Rostom Yosry Department of Radiation Oncology and Nuclear Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt aut Rashed Yaser Department of Medical Physics, Faculty of Medicine, Menofeya University, Shibeen Elkoom, Menofeya, Egypt aut Neurosurgical Review Springer-Verlag 34/1(2011-01-01), 87-99 0344-5607 34:1<87 2011 34 10143 https://doi.org/10.1007/s10143-010-0288-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10143-010-0288-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Abdelaziz Osama Department of Neurosurgery, Faculty of Medicine, Alexandria University, P.O. 21521, Alexandria, Egypt aut NATIONALLICENCE 700 1- Kandil Alaa Department of Radiation Oncology and Nuclear Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt aut NATIONALLICENCE 700 1- El-Assaal Shaaban Department of Radiation Oncology and Nuclear Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt aut NATIONALLICENCE 700 1- Abdelaziz Amro Department of Radiation Oncology and Nuclear Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt aut NATIONALLICENCE 700 1- Rostom Yosry Department of Radiation Oncology and Nuclear Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt aut NATIONALLICENCE 700 1- Rashed Yaser Department of Medical Physics, Faculty of Medicine, Menofeya University, Shibeen Elkoom, Menofeya, Egypt aut NATIONALLICENCE 773 0- Neurosurgical Review Springer-Verlag 34/1(2011-01-01), 87-99 0344-5607 34:1<87 2011 34 10143 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer