caa a22 4500 445329122 CHVBK 20180317142731.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s10143-011-0320-y doi (NATIONALLICENCE)springer-10.1007/s10143-011-0320-y Cytokine networks in glioma [Elektronische Daten] [Kenichiro Iwami, Atsushi Natsume, Toshihiko Wakabayashi] Glioma is the most frequently occurring brain tumor, but the prognosis of patients with gliomas remains poor despite advances in surgery, radiotherapy, and chemotherapy. Therefore, great efforts have been made to develop improved therapeutic strategies. Cytokines are a heterogeneous group of soluble small polypeptides or glycoproteins that exert pleiotropic and redundant effects that promote the growth, differentiation, and activation of normal cells. Cytokines have either pro- or anti-inflammatory activity and immunosuppressive activity, depending on the microenvironment surrounding the tumor. The microenvironment consists of heterogeneous tumor cells, immune cells, and extracellular matrix. Modulation of the microenvironment by the tumor is essential for its growth and progress. Cytokine production acts as a means of communication in the tumor microenvironment. In this article, we review the cross-talk between cytokines in the tumor microenvironment and the cytokine therapies that have been used till date for glioma treatment. Springer-Verlag, 2011 Glioma nationallicence Cancer immunology nationallicence Cytokine nationallicence Gene therapy nationallicence Iwami Kenichiro Department of Neurosurgery, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan aut Natsume Atsushi Department of Neurosurgery, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan aut Wakabayashi Toshihiko Department of Neurosurgery, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan aut Neurosurgical Review Springer-Verlag 34/3(2011-07-01), 253-264 0344-5607 34:3<253 2011 34 10143 https://doi.org/10.1007/s10143-011-0320-y text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10143-011-0320-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Iwami Kenichiro Department of Neurosurgery, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Natsume Atsushi Department of Neurosurgery, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Wakabayashi Toshihiko Department of Neurosurgery, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 773 0- Neurosurgical Review Springer-Verlag 34/3(2011-07-01), 253-264 0344-5607 34:3<253 2011 34 10143 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer