caa a22 4500 44532919X CHVBK 20180317142731.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10143-011-0326-5 doi (NATIONALLICENCE)springer-10.1007/s10143-011-0326-5 Pituitary insufficiency after operation of supratentorial intra- and extraaxial tumors outside of the sellar-parasellar region? [Elektronische Daten] [Dorothee Wachter, Nicole Gondermann, Matthias Oertel, Ulf Nestler, Veit Rohde, Dieter-Karsten Böker] Recent studies investigating pituitary function after non-sellar brain tumor surgery showed that up to 38.2% of patients have pituitary insufficiency (PI). It has been assumed that the operation causes the PI, but preoperative hormone testing, which would have been necessary to prove this assumption, was not performed. The objective of this study is to answer the question if indeed microsurgery is the culprit of PI in patients with operatively treated non-sellar brain tumors. In this prospective trial, 54 patients with supratentorial non-sellar tumors were included. The basal levels of cortisol, prolactin, testosterone, estrogen, IGF-1, fT3, fT4, STH, TSH, ACTH, FSH, and LH were recorded preoperatively on days1 and 7 after surgery. If basal hormone screening revealed an abnormality, a releasing hormone assay was performed. Before surgery, 24 of the 54 patients (44.4%) already had PI. Additional 25 patients showed either hypocortisolism or hypothyreoidism. As those patients had been pre-treated with dexamethasone and l-thyroxine, these findings were considered not to represent PI but drug effects. Hormone testing on days1 and 7 after surgery revealed no changes. With 44.4% PI is a frequent finding in brain tumor patients already before surgery. The factors causing preoperative PI remain yet to be identified. The endocrine results after surgery are unchanged which rules out that surgery is the cause of PI. The Author(s), 2011 Pituitary insufficiency nationallicence Non-sellar brain tumor nationallicence Quality of life nationallicence Brain tumor surgery nationallicence Wachter Dorothee Department of Neurosurgery, University Clinics of Giessen and Marburg GmbH, Campus Giessen, Klinikstrasse 29, 35392, Giessen, Germany aut Gondermann Nicole Department of Neurosurgery, University Clinics of Giessen and Marburg GmbH, Campus Giessen, Klinikstrasse 29, 35392, Giessen, Germany aut Oertel Matthias Department of Neurosurgery, University Clinics of Giessen and Marburg GmbH, Campus Giessen, Klinikstrasse 29, 35392, Giessen, Germany aut Nestler Ulf Department of Neurosurgery, University Clinics of Giessen and Marburg GmbH, Campus Giessen, Klinikstrasse 29, 35392, Giessen, Germany aut Rohde Veit Department of Neurosurgery, Georg-August-University Göttingen, Robert-Koch-Strasse 40, 37075, Göttingen, Germany aut Böker Dieter-Karsten Department of Neurosurgery, University Clinics of Giessen and Marburg GmbH, Campus Giessen, Klinikstrasse 29, 35392, Giessen, Germany aut Neurosurgical Review Springer-Verlag 34/4(2011-10-01), 509-516 0344-5607 34:4<509 2011 34 10143 https://doi.org/10.1007/s10143-011-0326-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10143-011-0326-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wachter Dorothee Department of Neurosurgery, University Clinics of Giessen and Marburg GmbH, Campus Giessen, Klinikstrasse 29, 35392, Giessen, Germany aut NATIONALLICENCE 700 1- Gondermann Nicole Department of Neurosurgery, University Clinics of Giessen and Marburg GmbH, Campus Giessen, Klinikstrasse 29, 35392, Giessen, Germany aut NATIONALLICENCE 700 1- Oertel Matthias Department of Neurosurgery, University Clinics of Giessen and Marburg GmbH, Campus Giessen, Klinikstrasse 29, 35392, Giessen, Germany aut NATIONALLICENCE 700 1- Nestler Ulf Department of Neurosurgery, University Clinics of Giessen and Marburg GmbH, Campus Giessen, Klinikstrasse 29, 35392, Giessen, Germany aut NATIONALLICENCE 700 1- Rohde Veit Department of Neurosurgery, Georg-August-University Göttingen, Robert-Koch-Strasse 40, 37075, Göttingen, Germany aut NATIONALLICENCE 700 1- Böker Dieter-Karsten Department of Neurosurgery, University Clinics of Giessen and Marburg GmbH, Campus Giessen, Klinikstrasse 29, 35392, Giessen, Germany aut NATIONALLICENCE 773 0- Neurosurgical Review Springer-Verlag 34/4(2011-10-01), 509-516 0344-5607 34:4<509 2011 34 10143 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer