caa a22 4500 44532936X CHVBK 20180317142732.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10143-010-0292-3 doi (NATIONALLICENCE)springer-10.1007/s10143-010-0292-3 Microbeam radiosurgery using synchrotron-generated submillimetric beams: a new tool for the treatment of brain disorders [Elektronische Daten] [David Anschel, Alberto Bravin, Pantaleo Romanelli] Since its advent during the mid-twentieth century, radiosurgery has undergone a steady evolution. Gamma Knife and linear accelerator based systems using rigid frames preceded the development of frameless devices. The present report describes the development of microbeam radiosurgery, a technique which uses submillimetric beams of radiation to treat disease. Typically, the technique is employed using parallel arrays of beams delivered via a high-fluence synchrotron source. Beam widths between 20 and 950μm have been used with the majority of studies utilizing beam widths less than 100μm. In addition to its high precision, the technique allows users to take advantage of two unique properties of microbeams. The first is a remarkable tolerance of healthy tissue to microbeams delivered at doses up to several hundred grays, while at the same time, tumors are highly susceptible to the lethal effects of microbeams. Together, these findings allow for a "preferential tumoricidal effect” beyond the typical dose-volume relationship. Although only used in animal experiments so far, we explore the hypothetical clinical role of microbeam radiosurgery which may be feasible in the near future. In addition to the treatment of traditional radiosurgery targets such as malignancies and vascular malformations, microbeams may allow the non-invasive treatment of functional disease such as movement disorders, epilepsy, and mental illness. Springer-Verlag, 2010 Microbeams nationallicence Microradiosurgery nationallicence Radiosurgery nationallicence Microbeam radiation therapy nationallicence Synchrotron nationallicence Brain nationallicence Anschel David Comprehensive Epilepsy Center of Long Island, 200 Belle Terre Road, 11778, Port Jefferson, NY, USA aut Bravin Alberto Biomedical Beamline ID17, European Synchrotron Radiation Facility, 6 rue J. Horowitz BP 220, 38043, Grenoble Cedex, France aut Romanelli Pantaleo Functional Neurosurgery, IRCCS Neuromed, Via Atinense 18, 86077, Pozzilli, IS, Italy aut Neurosurgical Review Springer-Verlag 34/2(2011-04-01), 133-142 0344-5607 34:2<133 2011 34 10143 https://doi.org/10.1007/s10143-010-0292-3 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10143-010-0292-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Anschel David Comprehensive Epilepsy Center of Long Island, 200 Belle Terre Road, 11778, Port Jefferson, NY, USA aut NATIONALLICENCE 700 1- Bravin Alberto Biomedical Beamline ID17, European Synchrotron Radiation Facility, 6 rue J. Horowitz BP 220, 38043, Grenoble Cedex, France aut NATIONALLICENCE 700 1- Romanelli Pantaleo Functional Neurosurgery, IRCCS Neuromed, Via Atinense 18, 86077, Pozzilli, IS, Italy aut NATIONALLICENCE 773 0- Neurosurgical Review Springer-Verlag 34/2(2011-04-01), 133-142 0344-5607 34:2<133 2011 34 10143 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer