caa a22 4500 445329394 CHVBK 20180317142732.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10143-010-0285-2 doi (NATIONALLICENCE)springer-10.1007/s10143-010-0285-2 Treatment of pituitary adenomas using radiosurgery and radiotherapy: a single center experience and review of literature [Elektronische Daten] [Daniel Sun, Jennifer Cheng, James Frazier, Sachin Batra, Gary Wand, Lawrence Kleinberg, Daniele Rigamonti, Alfredo Quinones-Hinojosa, Roberto Salvatori, Michael Lim] Fractionated radiotherapy (FRT) and gamma knife stereotactic radiosurgery (GKSRS) are used as adjuvant therapies to surgical resection for functional and non-functional pituitary adenomas, although their optimum role in the treatment algorithm, as well as long-term safety and efficacy, still awaits further study. We report a single center experience with 33 patients with non-functional (16 patients), ACTH- (five patients), GH- (four patients), or prolactin-secreting (eight patients) tumors treated with FRT or SRS. The median tumor diameter was 1.9cm, and the median follow-up was 36months. For GKSRS, the median dosage was 16Gy for non-functional adenomas and 23Gy for hormone-secreting tumors. The median total dose for FRT was 50.4Gy over 28 fractions (median). Two patients (6%) demonstrated radiographic evidence of tumor progression, three patients (9%) demonstrated radiation-induced visual field deficits on neuro-ophthalmic evaluation, and two patients (6%) suffered from radiation-induced hypopituitarism. Biochemical control, defined as normalized hormone values in the absence of medical therapy, was achieved in five out of eight prolactinoma patients and two out of five patients with Cushing's disease, but none of the four patients with acromegaly. These results are presented with a review of the relevant literature on the differential characteristics of FRT versus SRS in the treatment of functional and non-functional pituitary adenomas and validate postoperative irradiation as a potentially safe and effective means for tumor control. Springer-Verlag, 2010 Pituitary adenoma nationallicence Fractionated radiotherapy nationallicence Stereotactic radiosurgery nationallicence Sun Daniel Department of Neurosurgery, Johns Hopkins University School of Medicine, 21287, Baltimore, MD, USA aut Cheng Jennifer Department of Neurosurgery, Johns Hopkins University School of Medicine, 21287, Baltimore, MD, USA aut Frazier James Department of Neurosurgery, Johns Hopkins University School of Medicine, 21287, Baltimore, MD, USA aut Batra Sachin Department of Neurosurgery, Johns Hopkins University School of Medicine, 21287, Baltimore, MD, USA aut Wand Gary Department of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, 21287, Baltimore, MD, USA aut Kleinberg Lawrence Department of Radiation Oncology and Molecular Sciences, Johns Hopkins University School of Medicine, 21287, Baltimore, MD, USA aut Rigamonti Daniele Department of Neurosurgery, Johns Hopkins University School of Medicine, 21287, Baltimore, MD, USA aut Quinones-Hinojosa Alfredo Department of Neurosurgery, Johns Hopkins University School of Medicine, 21287, Baltimore, MD, USA aut Salvatori Roberto Department of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, 21287, Baltimore, MD, USA aut Lim Michael Department of Neurosurgery, Johns Hopkins University School of Medicine, 21287, Baltimore, MD, USA aut Neurosurgical Review Springer-Verlag 34/2(2011-04-01), 181-189 0344-5607 34:2<181 2011 34 10143 https://doi.org/10.1007/s10143-010-0285-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10143-010-0285-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sun Daniel Department of Neurosurgery, Johns Hopkins University School of Medicine, 21287, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Cheng Jennifer Department of Neurosurgery, Johns Hopkins University School of Medicine, 21287, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Frazier James Department of Neurosurgery, Johns Hopkins University School of Medicine, 21287, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Batra Sachin Department of Neurosurgery, Johns Hopkins University School of Medicine, 21287, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Wand Gary Department of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, 21287, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Kleinberg Lawrence Department of Radiation Oncology and Molecular Sciences, Johns Hopkins University School of Medicine, 21287, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Rigamonti Daniele Department of Neurosurgery, Johns Hopkins University School of Medicine, 21287, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Quinones-Hinojosa Alfredo Department of Neurosurgery, Johns Hopkins University School of Medicine, 21287, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Salvatori Roberto Department of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, 21287, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Lim Michael Department of Neurosurgery, Johns Hopkins University School of Medicine, 21287, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Neurosurgical Review Springer-Verlag 34/2(2011-04-01), 181-189 0344-5607 34:2<181 2011 34 10143 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer