caa a22 4500 445329408 CHVBK 20180317142732.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10143-010-0306-1 doi (NATIONALLICENCE)springer-10.1007/s10143-010-0306-1 Prognostic factors for patients with gliomatosis cerebri: retrospective analysis of 17 consecutive cases [Elektronische Daten] [Tomoo Inoue, Toshihiro Kumabe, Masayuki Kanamori, Yukihiko Sonoda, Mika Watanabe, Teiji Tominaga] Gliomatosis cerebri (GC) is a rare fatal glial neoplasm of the central nervous system. Neuroimaging, histological, and clinical outcome data were reviewed of 17 consecutive patients, 8 males and 9 females aged 15-68years (median, 37years), treated for GC between April 1992 and October 2007. All patients received cranial irradiation to include the hyperintense area on T2-weighted magnetic resonance imaging. The total dose of the radiotherapy was 50-72Gy (median, 60). Intravenous nimustine hydrochloride was administered in all patients, combined with temozolomide in four patients. The median survival time was 23.3months, with a median follow-up of 23.3months. Kaplan-Meier analysis demonstrated the overall survival rate which was 70.6% for 1year, 23.5% for 3years, and 17.7% for 5years. Spinal enhanced lesions and nodular malignant transformation to glioblastoma were observed during follow-up in two patients each. Poor survival showed correlation with higher Ki-67 labeling index, higher choline/N-acetylaspartate ratio on magnetic resonance spectroscopy, tumor volumes, lower Karnofsky performance status on admission, cognitive/behavioral deterioration, poor response to the initial radiochemotherapy, and emergence of paraventricular enhanced lesions during the clinical course. The prognosis for patients with GC is unfavorable, but radiochemotherapy may prolong survival. Springer-Verlag, 2011 Gliomatosis cerebri nationallicence Prognosis nationallicence Magnetic resonance imaging nationallicence Histopathology nationallicence Radiochemotherapy nationallicence Inoue Tomoo Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Japan aut Kumabe Toshihiro Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Japan aut Kanamori Masayuki Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Japan aut Sonoda Yukihiko Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Japan aut Watanabe Mika Department of Pathology, Tohoku University Hospital, Sendai, Miyagi, Japan aut Tominaga Teiji Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Japan aut Neurosurgical Review Springer-Verlag 34/2(2011-04-01), 197-208 0344-5607 34:2<197 2011 34 10143 https://doi.org/10.1007/s10143-010-0306-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10143-010-0306-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Inoue Tomoo Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Japan aut NATIONALLICENCE 700 1- Kumabe Toshihiro Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Japan aut NATIONALLICENCE 700 1- Kanamori Masayuki Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Japan aut NATIONALLICENCE 700 1- Sonoda Yukihiko Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Japan aut NATIONALLICENCE 700 1- Watanabe Mika Department of Pathology, Tohoku University Hospital, Sendai, Miyagi, Japan aut NATIONALLICENCE 700 1- Tominaga Teiji Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Japan aut NATIONALLICENCE 773 0- Neurosurgical Review Springer-Verlag 34/2(2011-04-01), 197-208 0344-5607 34:2<197 2011 34 10143 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer