caa a22 4500 445329904 CHVBK 20180317142734.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00285-010-0400-6 doi (NATIONALLICENCE)springer-10.1007/s00285-010-0400-6 A theoretical analysis of filament length fluctuations in actin and other polymers [Elektronische Daten] [Jifeng Hu, Hans Othmer] Control of the structure and dynamics of the actin cytoskeleton is essential for cell motility and for maintaining the structural integrity of cells. Central to understanding the control of these features is an understanding of the dynamics of actin filaments, first as isolated filaments, then as integrated networks, and finally as networks containing higher-order structures such as bundles, stress fibers and acto-myosin complexes. It is known experimentally that single filaments can exhibit large fluctuations, but a detailed understanding of the transient dynamics involved is still lacking. Here we first study stochastic models of a general system involving two-monomer types that can be analyzed completely, and then we report stochastic simulations on the complete actin model with three monomer types. We systematically examine the transient behavior of filament length dynamics so as to gain a better understanding of the time scales involved in reaching a steady state. We predict the lifetime of a cap of one monomer type and obtain the mean and variance of the survival time of a cap at the filament end, which together determine the filament length fluctuations. Springer-Verlag, 2011 Actin dynamics nationallicence Stochastic processes nationallicence Random walks on combs nationallicence Hu Jifeng School of Mathematics, University of Minnesota, 55455, Minneapolis, MN, USA aut Othmer Hans School of Mathematics, Digital Technology Center, University of Minnesota, 55455, Minneapolis, MN, USA aut Journal of Mathematical Biology Springer-Verlag 63/6(2011-12-01), 1001-1049 0303-6812 63:6<1001 2011 63 285 https://doi.org/10.1007/s00285-010-0400-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00285-010-0400-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hu Jifeng School of Mathematics, University of Minnesota, 55455, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Othmer Hans School of Mathematics, Digital Technology Center, University of Minnesota, 55455, Minneapolis, MN, USA aut NATIONALLICENCE 773 0- Journal of Mathematical Biology Springer-Verlag 63/6(2011-12-01), 1001-1049 0303-6812 63:6<1001 2011 63 285 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer