caa a22 4500 445329947 CHVBK 20180317142734.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00285-010-0382-4 doi (NATIONALLICENCE)springer-10.1007/s00285-010-0382-4 Selective sweeps for recessive alleles and for other modes of dominance [Elektronische Daten] [G. Ewing, J. Hermisson, P. Pfaffelhuber, J. Rudolf] A selective sweep describes the reduction of linked genetic variation due to strong positive selection. If s is the fitness advantage of a homozygote for the beneficial allele and h its dominance coefficient, it is usually assumed that h=1/2, i.e. the beneficial allele is co-dominant. We complement existing theory for selective sweeps by assuming that h is any value in [0, 1]. We show that genetic diversity patterns under selective sweeps with strength s and dominance 0<h<1 are similar to co-dominant sweeps with selection strength 2hs. Moreover, we focus on the case h=0 of a completely recessive beneficial allele. We find that the length of the sweep, i.e. the time from occurrence until fixation of the beneficial allele, is of the order of $${\sqrt{N/s}}$$ generations, if N is the population size. Simulations as well as our results show that genetic diversity patterns in the recessive case h=0 greatly differ from all other cases. Springer-Verlag, 2010 Genetic hitchhiking nationallicence Selective sweep nationallicence Beneficial mutation nationallicence Recessive allele nationallicence Genealogy nationallicence Ewing G. University of Vienna, Vienna, Austria aut Hermisson J. University of Vienna, Vienna, Austria aut Pfaffelhuber P. Albert-Ludwigs University of Freiburg, Freiburg, Germany aut Rudolf J. Albert-Ludwigs University of Freiburg, Freiburg, Germany aut Journal of Mathematical Biology Springer-Verlag 63/3(2011-09-01), 399-431 0303-6812 63:3<399 2011 63 285 https://doi.org/10.1007/s00285-010-0382-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00285-010-0382-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ewing G. University of Vienna, Vienna, Austria aut NATIONALLICENCE 700 1- Hermisson J. University of Vienna, Vienna, Austria aut NATIONALLICENCE 700 1- Pfaffelhuber P. Albert-Ludwigs University of Freiburg, Freiburg, Germany aut NATIONALLICENCE 700 1- Rudolf J. Albert-Ludwigs University of Freiburg, Freiburg, Germany aut NATIONALLICENCE 773 0- Journal of Mathematical Biology Springer-Verlag 63/3(2011-09-01), 399-431 0303-6812 63:3<399 2011 63 285 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer