caa a22 4500 445329998 CHVBK 20180317142734.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00285-010-0389-x doi (NATIONALLICENCE)springer-10.1007/s00285-010-0389-x Optimal orientation in branched cytoskeletal networks [Elektronische Daten] [D. Quint, J. Schwarz] Actin cytoskeletal protrusions in crawling cells, or lamellipodia, exhibit various morphological properties such as two characteristic peaks in the distribution of filament orientation with respect to the leading edge. To understand these properties, using the dendritic nucleation model as a basis for cytoskeletal restructuring, a kinetic-population model with orientational-dependent branching (birth) and capping (death) is constructed and analyzed. Optimizing for growth yields a relation between the branch angle and filament orientation that explains the two characteristic peaks. The model also exhibits a subdominant population that allows for more accurate modeling of recent measurements of filamentous actin density along the leading edge of lamellipodia in keratocytes. Finally, we explore the relationship between orientational and spatial organization of filamentous actin in lamellipodia and address recent observations of a prevalence of overlapping filaments to branched filaments—a finding that is claimed to be in contradiction with the dendritic nucleation model. Springer-Verlag, 2010 Actin cytoskeleton nationallicence Lamellipodia nationallicence Dendritic nucleation model nationallicence Quint D. Physics Department, Syracuse University, 13244, Syracuse, NY, USA aut Schwarz J. Physics Department, Syracuse University, 13244, Syracuse, NY, USA aut Journal of Mathematical Biology Springer-Verlag 63/4(2011-10-01), 735-755 0303-6812 63:4<735 2011 63 285 https://doi.org/10.1007/s00285-010-0389-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00285-010-0389-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Quint D. Physics Department, Syracuse University, 13244, Syracuse, NY, USA aut NATIONALLICENCE 700 1- Schwarz J. Physics Department, Syracuse University, 13244, Syracuse, NY, USA aut NATIONALLICENCE 773 0- Journal of Mathematical Biology Springer-Verlag 63/4(2011-10-01), 735-755 0303-6812 63:4<735 2011 63 285 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer