caa a22 4500 44533035X CHVBK 20180317142735.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00285-010-0339-7 doi (NATIONALLICENCE)springer-10.1007/s00285-010-0339-7 The influence of space dimension on the large-time behavior in a reaction-diffusion system modeling diallelic selection [Elektronische Daten] [Philippe Souplet, Michael Winkler] We study a mathematical model from population genetics, describing a single-locus diallelic (A/a) selection-migration process. The model consists of a coupled system of three reaction-diffusion equations, one for the density of each genotype, posed in the whole space $${\mathbb R^n}$$. The genotype AA is advantageous, due to a smaller death rate, and we consider the fully recessive case where the other two genotypes aa and Aa have the same (higher) death rate. In the nondiffusive (spatially homogeneous) case, the disadvantageous gene a is always eliminated in the large time limit. In the presence of diffusion, when the birth rate exceeds a certain threshold value, we prove that this conclusion is still true for dimensions n ≤ 2, whereas for n≥ 3 there exist initial distributions for which the advantageous gene A ultimately disappears. This is the first rigorous result of this type for the full system, and it solves a problem which seems to have been open since the celebrated work of Aronson and Weinberger (Lecture notes in mathematics, vol 446, Springer, New York, pp 5-49, 1975; Adv Math 30, 33-76, 1977), where similar results had been obtained for a simplified scalar model, that they derived as an approximation of the full system. Interestingly, we moreover show that, at the threshold value of the birth rate, the cut-off dimension shifts from n=2 to n=6. Springer-Verlag, 2010 Population genetics nationallicence Reaction-diffusion system nationallicence Selection nationallicence Extinction nationallicence Fisher approximation nationallicence Souplet Philippe Laboratoire Analyse Géométrie et Applications, Université Paris 13, CNRS UMR 7539, 93430, Villetaneuse, France aut Winkler Michael Fakultät für Mathematik, Universität Duisburg-Essen, 45117, Essen, Germany aut Journal of Mathematical Biology Springer-Verlag 62/3(2011-03-01), 391-421 0303-6812 62:3<391 2011 62 285 https://doi.org/10.1007/s00285-010-0339-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00285-010-0339-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Souplet Philippe Laboratoire Analyse Géométrie et Applications, Université Paris 13, CNRS UMR 7539, 93430, Villetaneuse, France aut NATIONALLICENCE 700 1- Winkler Michael Fakultät für Mathematik, Universität Duisburg-Essen, 45117, Essen, Germany aut NATIONALLICENCE 773 0- Journal of Mathematical Biology Springer-Verlag 62/3(2011-03-01), 391-421 0303-6812 62:3<391 2011 62 285 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer